| Week | Add | Drop |
| Pre-Season |
Round 1: C Keibert Ruiz - Was Round 3: RP Tommy Kahnle - Det Round A: 1B Kyle Manzardo - Cle |
Round A: 1B Yandy Diaz - TB |
| Week 1 |
Round 1: SS Ha-seong Kim - TB Round 2: RP Porter Hodge - ChN |
Round 1: RP Tommy Kahnle - Det |
| Week 2 |
Round 1: RP AJ Puk - Ari Round 2: OF Zac Veen - Col Round 3: RP Dennis Santana - Pit |
Round 1: C Drake Baldwin - Atl Round 2: RP Porter Hodge - ChN Round 3: RP AJ Puk - Ari |
| Week 3 |
Round 1: C Alejandro Kirk - Tor Round 2: SP Kumar Rocker - Tex Round 3: SS Adael Amador - Col |
Round 2: RP Dennis Santana - Pit Round 3: SP Kumar Rocker - Tex |
| Week 4 |
Round 1: RP Trevor Megill - Mil Round 3: RP David Bednar - Pit |
Round 1: SP Tanner Houck - Bos Round 2: SS Adael Amador - Col Round 3: SP Ronel Blanco - Hou |
| Week 5 |
Round 1: SP Ronel Blanco - Hou Round 2: 2B Christian Moore - LAA Round 3: 3B Ryan McMahon - Col |
Round 2: OF Zac Veen - Col Round 2: RP David Bednar - Pit Round 3: OF Michael Conforto - LAD |
| Week 6 |
Round 1: SP Lance McCullers - Hou Round 2: 3B Joey Ortiz - Mil |
Round 2: SP Ronel Blanco - Hou |
| 1st Team | 2nd Team |
| Pre-Season | |
| Ground Rule Double | Los Angeles White Sox |
|
SP
Logan Gilbert
Sea Round 7, 7th Pick (C Logan O'Hoppe LAA) |
OF
Dylan Crews
Was |
| Pre-Season | |
| Ground Rule Double | Miami Giants |
|
SS
Bo Bichette
Tor |
Round 4, 4th Pick (SP Kodai Senga NYN) |