| Week | Add | Drop |
| Pre-Season |
Round 1: RP Seth McClung  |
Round 1: SP Jon Lester  |
| Week 2 |
Round 1: SP Brandon McCarthy  |
Round 1: RP Seth McClung |
| Week 4 |
Round 1: SP Jason Hirsh  |
Round 1: SP Jeff Weaver  |
| Week 5 |
Round 1: OF Shane Victorino  |
Round 1: SP Jeff Francis |
| Week 6 |
Round 1: RP Josh Johnson |
| 1st Team | 2nd Team | Votes |
| Week 6 | ||
| Built 4 Speed | Boppers | Decision |
OF
Grady Sizemore
 |
SP
Kelvim Escobar
 SP Roy Oswalt  |
Approved 16-0. See Breakdown |