| Week | Add | Drop |
| Pre-Season |
Round 1: SP AJ Smith-Shawver - Atl Round 2: SP Erick Fedde - StL Round A: OF Garrett Mitchell - Mil Round B: 2B Luisangel Acuna - NYN |
Round 2: OF Jerar Encarnación - SF |
| Week 1 |
Round 1: OF Lars Nootbaar - StL Round 3: SP Max Meyer - Mia |
Round 1: C Dalton Rushing - LAD |
| Week 2 |
Round 1: SS Kyren Paris - LAA Round 2: OF Justyn-Henry Malloy - Det |
Round 2: 1B Matt Mervis - Mia |
| Week 3 |
Round 1: 3B Chase Meidroth - ChA |
Round 1: OF Alec Burleson - StL Round 2: SP AJ Smith-Shawver - Atl |
| Week 4 |
Round 1: OF Tim Tawa - Ari Round 2: SP Joe Boyle - TB Round 3: SP Matthew Liberatore - StL |
Round 1: 2B Gavin Lux - Cin Round 2: OF Garrett Mitchell - Mil Round 3: SP Joe Boyle - TB |
| Week 5 |
Round 1: 3B Matt Shaw - ChN Round 2: OF Trent Grisham - NYA |
Round 2: OF Justyn-Henry Malloy - Det |
| Week 6 |
Round 1: SP Luis Ortiz - Cle |
Round 1: 3B Joey Ortiz - Mil |
| 1st Team | 2nd Team |
| Pre-Season | |
| Las Vegas 51's | Northwest Arkansas Naturals |
|
OF
Wyatt Langford
Tex Round 12, 5th Pick (OF Walker Jenkins Min) |
3B
Josh Jung
Tex Round 2, 9th Pick (SP Kodai Senga NYN) |
| Pre-Season | |
| Las Vegas 51's | Brokeback Mountain |
|
Round 5, 5th Pick (RP Jhoan Duran Min) |
3B
Max Muncy
LAD |
| Pre-Season | |
| Las Vegas 51's | Pirates |
|
Round 1, 5th Pick (SP Jackson Jobe Det) |
2B
Ozzie Albies
Atl |
| Pre-Season | |
| Las Vegas 51's | The Plantation |
|
OF
Jarren Duran
Bos Round 10, 5th Pick (RP Ryan Pressly ChN) |
OF
Luis Robert Jr.
ChA Round 5, 8th Pick (C J.T. Realmuto Phi) |
| Week 6 | |
| Las Vegas 51's | Philippians |
|
OF
Riley Greene
Det |
1B
Jonathan Aranda
TB |