| Week | Add | Drop |
| Week 1 |
Round 1: SP Jon Rauch - Ari Round 2: OF Cliff Floyd - TB | |
| Week 2 |
Round 1: C Jason Kendall - Mil |
Round 1: SP Jason Schmidt - LAD |
| Week 3 |
Round 2: OF Angel Pagan - NYN |
Round 2: SS Alexei Ramirez - ChA |
| Week 4 |
Round 1: C Jeff Clement - Sea |
Round 1: C Ronny Paulino - Pit |
| Week 5 |
Round 1: OF Wladimir Balentien - Sea Round 2: OF Emil Brown - Oak |
Round 1: OF Angel Pagan - NYN Round 2: 2B Blake Dewitt - LAD |
| Week 6 |
Round 1: RP Justin Masterson - Bos Round 2: SP Jo-Jo Reyes - Atl |
Round 1: SP Johnny Cueto - Cin Round 2: RP Justin Masterson - Bos |
| Week 8 |
Round 1: SP Brian Burres - Bal |
Round 1: SP Jo-Jo Reyes - Atl |
| Week 10 |
Round 1: SS Alexei Ramirez - ChA Round 2: SP Jonathan Sanchez - SF |
Round 1: SP Brian Burres - Bal Round 2: SP John Smoltz - Bos |
| Week 12 |
Round 1: 1B Chris Davis - Tex |
Round 1: C Jason Kendall - Mil |
| Week 13 |
Round 1: OF Elijah Dukes - Was Round 2: OF Skip Schumaker - StL |
Round 1: OF Emil Brown - Oak Round 2: OF Cliff Floyd - SD |
| Week 14 |
Round 1: OF Andrew McCutchen - Pit Round 2: DH Hank Blalock - Tex | |
| Week 15 |
Round 2: 3B Bill Hall - Mil | |
| Week 21 |
Round 1: RP Brandon Morrow - Sea |
Round 1: OF Skip Schumaker - StL |
| 1st Team | 2nd Team | Votes |
| Week 4 | ||
| Outcasts I | Dangerous Dave | Decision |
|
3B
Joe Crede
ChA SP Ian Snell Pit |
SP
Dontrelle Willis
Det 1B Daric Barton Oak |
Approved 17-2. See Breakdown |
| Week 4 | ||
| Outcasts I | Angels | Decision |
|
OF
Vernon Wells
Tor 1B Justin Morneau Min SP Dan Haren Ari |
SP
Ben Sheets
Mil 1B Albert Pujols StL 2B Blake Dewitt LAD |
Approved 16-3. See Breakdown |
| Week 6 | ||
| Outcasts I | Angels | Decision |
|
OF
Nick Markakis
Bal SP Matt Garza TB |
SP
John Smoltz
Bos OF Brad Hawpe Col |
Approved 15-2. See Breakdown |
| Week 6 | ||
| Outcasts I | Twins Rock | Decision |
|
OF
Kosuke Fukudome
ChN |
1B
Kevin Youkilis
Bos |
Approved 17-0. See Breakdown |
| Week 10 | ||
| Outcasts I | Dangerous Dave | Decision |
|
OF
Justin Upton
Ari |
SS
Derek Jeter
NYA |
Approved 16-2. See Breakdown |
| Week 13 | ||
| Outcasts I | Angels | Decision |
|
SS
J.J. Hardy
Mil OF Brad Hawpe Col SP Chris Young SD |
SP
A.J. Burnett
Tor OF Nick Swisher ChA SP Matt Cain SF |
Approved 18-0. See Breakdown |
| Week 13 | ||
| Outcasts I | Dangerous Dave | Decision |
|
1B
Joey Votto
Cin |
RP
Ryan Dempster
ChN |
Approved 18-0. See Breakdown |