| Week | Add | Drop |
| Pre-Season |
Round 1: DH Mitch Garver - Sea Round 2: SP Kyle Hendricks - ChN | |
| Week 1 |
Round 1: SP Reid Detmers - LAA Round 2: OF Michael Conforto - SF | |
| Week 3 |
Round 1: SS Blaze Alexander - Ari Round 2: 2B Davis Schneider - Tor |
Round 1: DH Mitch Garver - Sea Round 2: C Danny Jansen - Tor |
| Week 4 |
Round 1: OF Starling Marte - NYN |
Round 1: 2B Davis Schneider - Tor |
| Week 5 |
Round 1: C Patrick Bailey - SF |
Round 1: SP Kyle Hendricks - ChN |
| Week 6 |
Round 1: 2B Willi Castro - Min Round 2: OF Wenceel Perez - Det |
Round 1: C Patrick Bailey - SF Round 2: OF Parker Meadows - Det |
| 1st Team | 2nd Team |
| Pre-Season | |
| Durham Bulls | Rabble-Rousers |
|
2B
Zack Gelof
Oak |
Round 5, 6th Pick (1B Anthony Rizzo NYA) |
| Pre-Season | |
| Durham Bulls | Twins Rock |
|
Round 5, 3rd Pick (SP Triston McKenzie Cle) Round 12, 3rd Pick (OF Lourdes Gurriel Ari) |
OF
Eloy Jimenez
ChA |