| Week | Add | Drop |
| Pre-Season |
Round 1: 3B Graham Pauley - SD Round 2: SP Cade Horton - ChN Round A: C Luis Campusano - SD Round B: C Bo Naylor - Cle Round C: SP Kyle Harrison - SF Round D: SS Colson Montgomery - ChA |
Round 1: DH Justin Foscue - Tex |
| Week 1 |
Round 1: 1B Jared Walsh - ChA Round 2: SP Brady Singer - KC |
Round 2: SP Ricky Tiedemann - Tor |
| Week 2 |
Round 1: SP Cody Bradford - Tex Round 2: SP Yariel Rodriguez - Tor |
Round 2: 3B Graham Pauley - SD |
| Week 3 |
Round 1: OF Brandon Marsh - Phi Round 2: SP Simeon Woods Richardson - Min |
Round 1: 2B Davis Schneider - Tor Round 2: SP Hunter Brown - Hou |
| Week 4 |
Round 1: SP Ryan Weathers - Mia Round 2: 2B Michael Massey - KC |
Round 1: SP Simeon Woods Richardson - Min Round 2: 1B Jared Walsh - ChA |
| Week 5 |
Round 1: 1B Kyle Manzardo - Cle Round 2: OF Jo Adell - LAA |
Round 1: OF Chas McCormick - Hou Round 2: SP Ryan Weathers - Mia |
| Week 6 |
Round 1: SP Taj Bradley - TB |
Round 1: SP Yariel Rodriguez - Tor Round 2: C Gabriel Moreno - Ari |
| 1st Team | 2nd Team |
| Pre-Season | |
| Rabble-Rousers | Beane Ballers |
|
OF
Juan Soto
NYA |
SS
Bo Bichette
Tor SP Grayson Rodriguez Bal OF Evan Carter Tex |
| Pre-Season | |
| Rabble-Rousers | Homestead Grays |
|
SP
Chase Silseth
LAA |
Round 3, 9th Pick (OF Chas McCormick Hou) |
| Pre-Season | |
| Rabble-Rousers | Twins Rock |
|
C
Endy Rodriguez
Pit |
Round 5, 12th Pick (OF Spencer Jones NYA) |
| Pre-Season | |
| Rabble-Rousers | Red Devils |
|
3B
Jake Burger
Mia |
Round 7, 10th Pick (DH Justin Foscue Tex) |
| Pre-Season | |
| Rabble-Rousers | Durham Bulls |
|
Round 5, 6th Pick (1B Anthony Rizzo NYA) |
2B
Zack Gelof
Oak |
| Pre-Season | |
| Rabble-Rousers | Zephaniah |
|
SP
Pablo Lopez
Min |
Round 3, 2nd Pick (3B Ke'Bryan Hayes Pit) |