| Week | Add | Drop |
| Pre-Season |
Round 1: SP Max Meyer - Mia Round 2: DH Mitch Garver - Sea |
Round 1: 3B Curtis Mead - TB |
| Week 1 |
Round 1: RP Abner Uribe - Mil Round 2: RP Daniel Hudson - LAD | |
| Week 2 |
Round 1: RP Michael Kopech - ChA |
Round 1: SP Shane Bieber - Cle |
| Week 3 |
Round 1: OF Max Kepler - Min |
Round 1: RP Daniel Hudson - LAD |
| Week 4 |
Round 1: SS Amed Rosario - TB |
Round 1: DH Mitch Garver - Sea |
| Week 5 |
Round 1: RP Orion Kerkering - Phi Round 2: RP Kevin Ginkel - Ari |
Round 1: RP Abner Uribe - Mil Round 2: SS J.P. Crawford - Sea |
| Week 6 |
Round 1: SP Brandon Pfaadt - Ari Round 2: SP Dean Kremer - Bal |
Round 1: RP Kevin Ginkel - Ari Round 2: OF Jarred Kelenic - Atl |
| 1st Team | 2nd Team |
| Pre-Season | |
| Horseheads Buffalos | Clinton LumberKings |
|
SP
Pablo Lopez
Min |
Round 7, 2nd Pick (RP Peter Fairbanks TB) |
| Pre-Season | |
| Horseheads Buffalos | Salt Lake Bees |
|
1B
Triston Casas
Bos |
Round 3, 11th Pick (SP Merrill Kelly Ari) |
| Pre-Season | |
| Horseheads Buffalos | NYSE: EA |
|
OF
Jazz Chisholm
Mia |
Round 4, 7th Pick (SP Sonny Gray StL) |
| Week 5 | |
| Horseheads Buffalos | Akron RubberDucks |
|
1B
Joshua Bell
Mia |
OF
Jarred Kelenic
Atl |