| Week | Add | Drop |
| Pre-Season |
Round 1: SP Drew Rasmussen - TB Round 3: RP Tommy Kahnle - Det Round A: SS Sebastian Walcott - Tex |
Round 3: 1B Andrew Vaughn - ChA Round A: SS Amed Rosario - Was |
| Week 1 |
Round 1: C Sean Murphy - Atl Round 2: SS Ha-seong Kim - TB Round 3: RP Porter Hodge - ChN |
Round 1: RP Tommy Kahnle - Det |
| Week 2 |
Round 1: SP Casey Mize - Det Round 2: OF Zac Veen - Col Round 3: 1B Joshua Bell - Was |
Round 1: 3B Brett Baty - NYN Round 2: RP Porter Hodge - ChN Round 2: OF Victor Robles - Sea Round 3: SS J.P. Crawford - Sea |
| Week 3 |
Round 1: 3B Noelvi Marte - Cin Round 2: SP Andrew Painter - Phi Round 3: SS Adael Amador - Col |
Round 3: C Danny Jansen - TB |
| Week 4 |
Round 1: RP Trevor Megill - Mil Round 2: SP Shane Bieber - Cle Round 3: RP David Bednar - Pit |
Round 1: RP Jordan Romano - Phi Round 2: SS Adael Amador - Col Round 3: SP Andrew Painter - Phi |
| Week 5 |
Round 1: SP Ronel Blanco - Hou Round 2: 1B Michael Toglia - Col Round 3: RP Will Vest - Det |
Round 1: OF Zac Veen - Col Round 2: RP David Bednar - Pit Round 3: 1B Joshua Bell - Was |
| Week 6 |
Round 1: C Tyler Stephenson - Cin |
Round 1: SP Ronel Blanco - Hou |
| 1st Team | 2nd Team |
| Pre-Season | |
| Horseheads Buffalos | STDS |
|
SP
Logan Gilbert
Sea |
Round 3, 3rd Pick (SP Kevin Gausman Tor) |
| Pre-Season | |
| Horseheads Buffalos | Outcasts II |
|
SS
Bo Bichette
Tor |
Round 3, 1st Pick (SP Luis Castillo Sea) |
| Pre-Season | |
| Horseheads Buffalos | Ambulance Chasers |
|
3B
Coby Mayo
Bal |
Round 7, 2nd Pick (SP Clay Holmes NYN) |
| Pre-Season | |
| Horseheads Buffalos | Bad Reputation |
|
Round 1, 10th Pick (SP Tyler Glasnow LAD) |
2B
Jackson Holliday
Bal |