| Week | Add | Drop |
| Pre-Season |
Round 1: 3B Miguel Vargas  Round 2: SP Clarke Schmidt  Round 3: 2B Edouard Julien  Round A: OF Garrett Mitchell  | |
| Week 1 |
Round 1: SP Jeffrey Springs  Round 2: OF Heston Kjerstad  Round 3: SP Bowden Francis  | |
| Week 2 |
Round 1: SP Chase Dollander  Round 2: OF Justyn-Henry Malloy  Round 3: OF Tim Tawa  |
Round 1: SP Nick Martinez  Round 2: OF Andy Pages  Round 3: SP Hayden Birdsong  |
| Week 3 |
Round 1: SP Zebby Matthews |
Round 1: RP Jordan Romano  |
| Week 4 |
Round 1: 2B Luke Keaschall Round 2: OF Chandler Simpson  Round 3: SP Andrew Heaney |
Round 1: 2B Edouard Julien Round 2: OF Joc Pederson  Round 3: 3B Miguel Vargas |
| Week 5 |
Round 1: SP Brayan Bello  Round 2: SP Ryan Gusto  |
Round 1: OF Justyn-Henry Malloy Round 2: SP Simeon Woods Richardson |
| Week 6 |
Round 1: OF Kyle Stowers Round 3: SP Gunnar Hoglund |
Round 1: SP Clarke Schmidt Round 3: SP Bowden Francis |
| Week 7 |
Round 1: C Moises Ballesteros  Round 2: OF Rece Hinds |
Round 1: C Gabriel Moreno Round 2: SP Chase Dollander |
| Week 8 |
Round 2: OF Addison Barger Round 3: 3B Matt Lugo  |
Round 2: SP Ryan Gusto |
| Week 9 |
Round 1: OF Robert Hassell  Round 2: 3B Curtis Mead |
Round 2: OF Rece Hinds |
| Week 10 |
Round 1: C Kyle Teel Round 2: SS Cole Young  Round 3: OF Jorge Soler |
Round 1: SP Gunnar Hoglund Round 2: OF Chandler Simpson Round 3: 3B Matt Lugo |
| Week 11 |
Round 1: OF Justin Crawford Round 2: SS Ronny Mauricio  |
Round 1: SP Max Meyer Round 2: RP Ryan Walker |
| Week 12 |
Round 1: SP Jacob Misiorowski Round 2: SP Bryce Elder  Round 3: 1B C.J. Kayfus  |
Round 1: SP Ryan Weathers Round 2: SP Zebby Matthews Round 3: OF Tim Tawa |
| Week 13 |
Round 1: SP Emmet Sheehan Round 3: OF Mickey Moniak |
Round 1: OF Robert Hassell Round 3: SP Bryce Elder |
| Week 14 |
Round 1: SP Landen Roupp Round 2: SP Will Warren |
Round 1: OF Jorge Soler Round 2: SS Cole Young |
| Week 15 |
Round 1: SS Carson Williams |
Round 1: C Jonah Heim |
| Week 16 |
Round 1: SP Slade Cecconi Round 2: OF Giancarlo Stanton |
Round 2: 2B Zack Gelof |
| Week 18 |
Round 1: C Francisco Álvarez Round 2: SP Michael McGreevy  |
Round 1: OF Tyler O'Neill Round 2: SP Andrew Heaney |
| Week 19 |
Round 1: 3B Sal Stewart |
Round 1: 3B Curtis Mead |
| Week 20 |
Round 1: DH Jhostynxon Garcia Round 2: SP Nolan McLean |
Round 1: SP Walker Buehler Round 2: SP Michael McGreevy |
| Week 22 |
Round 1: OF Colby Thomas Round 2: C Dalton Rushing Round 3: OF Luis Matos |
Round 1: SP Jeffrey Springs Round 2: SP Slade Cecconi Round 3: SP Landen Roupp |
| Week 24 |
Round 1: SP Payton Tolle Round 2: OF Parker Meadows |
Round 1: OF Luis Matos Round 2: SP Emmet Sheehan |
| 1st Team | 2nd Team |
| Pre-Season | |
| Portland Sea Dogs | Built 4 Speed |
|
Round 7, 7th Pick (3B Nolan Arenado ) |
SP
Bryan Woo
|
| Pre-Season | |
| Portland Sea Dogs | My Bad |
|
Round 1, 7th Pick (SP Cristopher Sanchez ) |
3B
Josh Jung
|
| Pre-Season | |
| Portland Sea Dogs | The Plantation |
SP
Framber Valdez
 OF Spencer Steer |
Round 2, 3rd Pick (RP Edwin Diaz ) Round 5, 3rd Pick (1B Rhys Hoskins ) |
| Pre-Season | |
| Portland Sea Dogs | Whiz Kids |
|
Round 3, 7th Pick (OF Pete Crow-Armstrong ) |
SP
Aaron Nola
|
| Week 7 | |
| Portland Sea Dogs | Whiz Kids |
|
OF
Christian Yelich
SP Aaron Nola 1B Rhys Hoskins |
OF
Tyler O'Neill
SP Max Meyer SP Eury Perez C Samuel Basallo |
| Week 8 | |
| Portland Sea Dogs | The Plantation |
|
RP
Edwin Diaz
|
|
| Week 9 | |
| Portland Sea Dogs | High Point Rockers |
|
1B
Triston Casas
|
|
| Week 14 | |
| Portland Sea Dogs | Twins Rock |
|
SP
Bryan Woo
|
SP
Grayson Rodriguez
|
| Week 16 | |
| Portland Sea Dogs | High Point Rockers |
|
SP
Eury Perez
|
|