| Week | Add | Drop |
| Pre-Season |
Round A: 1B Munetaka Murakami  Round B: SP Emmet Sheehan  |
Round A: SS J.P. Crawford  Round B: C Dalton Rushing |
| Week 1 |
Round 1: SP Cody Ponce  Round 2: 1B Deyvison De Los Santos  Round 3: SP Lance McCullers  | |
| Week 2 |
Round 1: SP Adrian Houser  |
Round 1: SP Cody Ponce |
| Week 3 |
Round 1: SP Javier Assad  Round 2: 3B Alex Freeland |
Round 1: 3B Kyle Karros  Round 2: SP Adrian Houser |
| Week 4 |
Round 1: RP Steven Matz  Round 3: SP Carmen Mlodzinski  |
Round 1: 1B Mark Vientos  Round 3: 1B Deyvison De Los Santos |
| Week 5 |
Round 1: SP Colin Rea Round 2: SP Dustin May  |
Round 1: 3B Alex Freeland Round 2: SP Nick Pivetta  |
| 1st Team | 2nd Team |
| Pre-Season | |
| Portland Sea Dogs | Twins Rock |
|
SP
Nolan McLean
|
OF
Teoscar Hernández
|
| Pre-Season | |
| Portland Sea Dogs | Twins Rock |
|
Round 9, 2nd Pick (OF Heliot Ramos ) Round 11, 2nd Pick (OF Sal Frelick  )Round 12, 2nd Pick (SP Ryne Nelson  )Round 15, 2nd Pick (SP Joey Cantillo  ) |
Round 7, 3rd Pick (RP Trevor Megill ) |
| Pre-Season | |
| Portland Sea Dogs | Built 4 Speed |
OF
Jarren Duran
 |
OF
Oneil Cruz
SS Colson Montgomery |
| Pre-Season | |
| Portland Sea Dogs | Whiz Kids |
|
Round 5, 2nd Pick (OF Jordan Lawlar ) |
SP
Jesus Luzardo
 |
| Pre-Season | |
| Portland Sea Dogs | DRIVEWAY DRINKERS |
|
OF
Jackson Merrill
|
OF
Mike Trout
 3B Bo Bichette Round 9, 9th Pick (SP Blake Snell ) |