| Week | Add | Drop |
| Pre-Season |
Round A: 1B Munetaka Murakami  Round B: SP Emmet Sheehan  |
Round A: SS J.P. Crawford  Round B: C Dalton Rushing |
| Week 1 |
Round 1: SP Cody Ponce  Round 2: 1B Deyvison De Los Santos  Round 3: SP Lance McCullers  | |
| Week 2 |
Round 1: SP Adrian Houser  |
Round 1: SP Cody Ponce |
| Week 3 |
Round 1: SP Javier Assad  Round 2: 3B Alex Freeland |
Round 1: 3B Kyle Karros  Round 2: SP Adrian Houser |
| Week 4 |
Round 1: RP Steven Matz  Round 3: SP Carmen Mlodzinski  |
Round 1: 1B Mark Vientos  Round 3: 1B Deyvison De Los Santos |
| Week 5 |
Round 1: SP Colin Rea Round 2: SP Dustin May  Round 3: SP Jack Kochanowicz  |
Round 1: 3B Alex Freeland Round 2: SP Nick Pivetta  Round 3: SP Lance McCullers |
| Week 7 |
Round 1: 2B Bryson Stott  Round 2: 1B Mark Vientos |
Round 1: SP Javier Assad Round 2: SP Quinn Priester  |
| Week 8 |
Round 1: SS Edwin Arroyo  |
Round 1: RP Trevor Megill |
| Week 9 |
Round 1: 1B Yohandy Morales  Round 2: OF Miguel Andújar |
Round 1: SP Jameson Taillon Round 2: SS Trevor Story  |
| Week 10 |
Round 1: 2B Ernie Clement |
Round 1: SP Jack Kochanowicz |
| Week 11 |
Round 1: SP Zack Littell Round 2: OF Joc Pederson  Round 3: SP Noah Cameron  |
Round 1: SP Carmen Mlodzinski Round 2: 2B Bryson Stott Round 3: RP Steven Matz |
| Week 12 |
Round 1: OF Cole Carrigg Round 2: RP Alex Lange Round 3: C Drew Cavanaugh |
Round 1: 1B Mark Vientos Round 2: OF TJ Friedl Round 3: OF Miguel Andújar |
| Week 13 |
Round 1: 3B Kyle Karros Round 2: SP Brady Singer Round 3: OF Jonny DeLuca |
Round 1: RP Alex Lange Round 2: OF Evan Carter Round 3: SP Colin Rea |
| Week 14 |
Round 2: C Victor Caratini  Round 3: SP Eric Lauer |
Round 2: 2B Ernie Clement Round 3: 3B Kyle Karros |
| Week 15 |
Round 1: SS Jacob Gonzalez |
Round 1: C J.T. Realmuto |
| 1st Team | 2nd Team |
| Pre-Season | |
| Portland Sea Dogs | Twins Rock |
|
SP
Nolan McLean
|
OF
Teoscar Hernández
|
| Pre-Season | |
| Portland Sea Dogs | Twins Rock |
|
Round 9, 2nd Pick (OF Heliot Ramos ) Round 11, 2nd Pick (OF Sal Frelick )Round 12, 2nd Pick (SP Ryne Nelson  )Round 15, 2nd Pick (SP Joey Cantillo  ) |
Round 7, 3rd Pick (RP Trevor Megill ) |
| Pre-Season | |
| Portland Sea Dogs | Built 4 Speed |
|
OF
Jarren Duran
|
OF
Oneil Cruz
SS Colson Montgomery |
| Pre-Season | |
| Portland Sea Dogs | Whiz Kids |
|
Round 5, 2nd Pick (OF Jordan Lawlar ) |
SP
Jesus Luzardo
|
| Pre-Season | |
| Portland Sea Dogs | DRIVEWAY DRINKERS |
|
OF
Jackson Merrill
|
OF
Mike Trout
3B Bo Bichette Round 9, 9th Pick (SP Blake Snell ) |
| Week 11 | |
| Portland Sea Dogs | High Point Rockers |
|
OF
Mike Trout
SP Michael King |
C
J.T. Realmuto
OF TJ Friedl |
| Week 13 | |
| Portland Sea Dogs | Built 4 Speed |
C
Samuel Basallo
 SP Andrew Painter 2B Luke Keaschall |
SP
Freddy Peralta
2B Nico Hoerner OF Jarren Duran |
| Week 14 | |
| Portland Sea Dogs | My Bad |
|
OF
Joc Pederson
3B Royce Lewis RP Devin Williams SP Nick Lodolo SP Tarik Skubal  |
SS
Francisco Lindor
SP Gerrit Cole  SP Framber Valdez OF Seiya Suzuki 3B Kazuma Okamoto |