| Week | Add | Drop |
| Pre-Season |
Round 1: 3B Miguel Vargas - ChA Round 2: SP Clarke Schmidt - NYA Round 3: 2B Edouard Julien - Min Round A: OF Garrett Mitchell - Mil | |
| Week 1 |
Round 1: SP Jeffrey Springs - Oak Round 2: OF Heston Kjerstad - Bal Round 3: SP Bowden Francis - Tor | |
| Week 2 |
Round 1: SP Chase Dollander - Col Round 2: OF Justyn-Henry Malloy - Det Round 3: OF Tim Tawa - Ari |
Round 1: SP Nick Martinez - Cin Round 2: OF Andy Pages - LAD Round 3: SP Hayden Birdsong - SF |
| Week 3 |
Round 1: SP Zebby Matthews - Min |
Round 1: RP Jordan Romano - Phi |
| Week 4 |
Round 1: 2B Luke Keaschall - Min Round 2: OF Chandler Simpson - TB Round 3: SP Andrew Heaney - Pit |
Round 1: 2B Edouard Julien - Min Round 2: OF Joc Pederson - Tex Round 3: 3B Miguel Vargas - ChA |
| Week 5 |
Round 1: SP Brayan Bello - Bos Round 2: SP Ryan Gusto - Hou |
Round 1: OF Justyn-Henry Malloy - Det Round 2: SP Simeon Woods Richardson - Min |
| Week 6 |
Round 1: OF Kyle Stowers - Mia Round 3: SP Gunnar Hoglund - Oak |
Round 1: SP Clarke Schmidt - NYA Round 3: SP Bowden Francis - Tor |
| Week 7 |
Round 1: C Moises Ballesteros - ChN Round 2: OF Rece Hinds - Cin |
Round 1: C Gabriel Moreno - Ari Round 2: SP Chase Dollander - Col |
| Week 8 |
Round 2: OF Addison Barger - Tor Round 3: 3B Matt Lugo - LAA |
Round 2: SP Ryan Gusto - Hou |
| Week 9 |
Round 1: OF Robert Hassell - Was Round 2: 3B Curtis Mead - TB |
Round 2: OF Rece Hinds - Cin |
| Week 10 |
Round 1: C Kyle Teel - ChA Round 2: SS Cole Young - Sea Round 3: OF Jorge Soler - LAA |
Round 1: SP Gunnar Hoglund - Oak Round 2: OF Chandler Simpson - TB Round 3: 3B Matt Lugo - LAA |
| Week 11 |
Round 1: OF Justin Crawford - Phi Round 2: SS Ronny Mauricio - NYN |
Round 1: SP Max Meyer - Mia Round 2: RP Ryan Walker - SF |
| Week 12 |
Round 1: SP Jacob Misiorowski - Mil Round 2: SP Bryce Elder - Atl Round 3: 1B C.J. Kayfus - Cle |
Round 1: SP Ryan Weathers - Mia Round 2: SP Zebby Matthews - Min Round 3: OF Tim Tawa - Ari |
| Week 13 |
Round 1: SP Emmet Sheehan - LAD Round 3: OF Mickey Moniak - Col |
Round 1: OF Robert Hassell - Was Round 3: SP Bryce Elder - Atl |
| Week 14 |
Round 1: SP Landen Roupp - SF Round 2: SP Will Warren - NYA |
Round 1: OF Jorge Soler - LAA Round 2: SS Cole Young - Sea |
| Week 15 |
Round 1: SS Carson Williams - TB |
Round 1: C Jonah Heim - Tex |
| 1st Team | 2nd Team |
| Pre-Season | |
| Portland Sea Dogs | Built 4 Speed |
|
Round 7, 7th Pick (3B Nolan Arenado StL) |
SP
Bryan Woo
Sea |
| Pre-Season | |
| Portland Sea Dogs | My Bad |
|
Round 1, 7th Pick (SP Cristopher Sanchez Phi) |
3B
Josh Jung
Tex |
| Pre-Season | |
| Portland Sea Dogs | The Plantation |
|
SP
Framber Valdez
Hou OF Spencer Steer Cin |
Round 2, 3rd Pick (RP Edwin Diaz NYN) Round 5, 3rd Pick (1B Rhys Hoskins Mil) |
| Pre-Season | |
| Portland Sea Dogs | Whiz Kids |
|
Round 3, 7th Pick (OF Pete Crow-Armstrong ChN) |
SP
Aaron Nola
Phi |
| Week 7 | |
| Portland Sea Dogs | Whiz Kids |
|
OF
Christian Yelich
Mil SP Aaron Nola Phi 1B Rhys Hoskins Mil |
OF
Tyler O'Neill
Bal SP Max Meyer Mia SP Eury Perez Mia C Samuel Basallo Bal |
| Week 8 | |
| Portland Sea Dogs | The Plantation |
|
RP
Edwin Diaz
NYN |
|
| Week 9 | |
| Portland Sea Dogs | High Point Rockers |
|
1B
Triston Casas
Bos |
|
| Week 14 | |
| Portland Sea Dogs | Twins Rock |
|
SP
Bryan Woo
Sea |
SP
Grayson Rodriguez
Bal |