| Week | Add | Drop |
| Pre-Season |
Round A: OF Evan Carter - Tex Round B: OF Jo Adell - LAA |
Round A: 3B Jake Burger - Mia Round B: OF Michael Conforto - SF |
| Week 1 |
Round 1: RP Abner Uribe - Mil Round 2: 3B Ezequiel Duran - Tex |
Round 2: RP Alex Lange - Det |
| Week 2 |
Round 1: 3B Trey Lipscomb - Was | |
| Week 3 |
Round 1: SP Sean Manaea - NYN Round 2: RP Michael Kopech - LAD |
Round 1: 3B Ezequiel Duran - Tex Round 2: SP Sean Manaea - NYN |
| Week 4 |
Round 1: SP Jesus Luzardo - Mia Round 2: SP Christian Scott - NYN |
Round 1: 3B Trey Lipscomb - Was Round 2: C Henry Davis - Pit |
| Week 5 |
Round 1: RP Orion Kerkering - Phi Round 2: RP Yennier Cano - Bal |
Round 1: RP Abner Uribe - Mil |
| Week 6 |
Round 1: 3B Tyler Black - Mil Round 2: RP Daniel Hudson - LAD |
Round 1: RP Yennier Cano - Bal Round 2: RP Orion Kerkering - Phi |
| Week 7 |
Round 1: OF Blake Perkins - Mil Round 2: OF Jonny DeLuca - TB |
Round 1: OF James Outman - LAD Round 2: OF Blake Perkins - Mil Round 2: RP Michael Kopech - LAD |
| Week 8 |
Round 1: SS J.P. Crawford - Sea Round 2: RP Tanner Scott - SD |
Round 2: RP Daniel Hudson - LAD |
| Week 9 |
Round 1: OF JJ Bleday - Oak Round 1: OF JJ Bleday - Oak Round 2: RP Tanner Scott - SD |
Round 1: RP Tanner Scott - SD Round 1: RP Tanner Scott - SD Round 2: OF Mitch Haniger - Sea Round 2: SP Kyle Bradish - Bal |
| Week 10 |
Round 2: OF Mike Tauchman - ChN |
Round 2: OF Jonny DeLuca - TB |
| Week 11 |
Round 1: RP Jason Foley - Det Round 2: 2B Jorge Polanco - Sea |
Round 2: SP Jesus Luzardo - Mia |
| Week 12 |
Round 1: SP Shane Baz - TB |
Round 1: 3B Tyler Black - Mil |
| Week 13 |
Round 1: OF Masataka Yoshida - Bos Round 2: SP Max Meyer - Mia |
Round 1: OF Mike Tauchman - ChN Round 2: SP Nick Pivetta - Bos |
| Week 15 |
Round 1: 3B Orelvis Martinez - Tor |
Round 1: RP Tanner Scott - SD |
| Week 16 |
Round 1: OF Rece Hinds - Cin | |
| Week 18 |
Round 1: SS Max Muncy - Oak Round 2: 2B Xavier Edwards - Mia |
Round 1: C Bo Naylor - Cle Round 2: SS J.P. Crawford - Sea |
| Week 19 |
Round 1: 2B Christian Moore - LAA |
Round 1: SP Christian Scott - NYN |
| 1st Team | 2nd Team |
| Pre-Season | |
| My Bad | Whiz Kids |
|
2B
Whit Merrifield
Atl |
|
| Pre-Season | |
| My Bad | Bad Reputation |
|
SP
Pablo Lopez
Min |
|
| Pre-Season | |
| My Bad | Bad Reputation |
|
3B
Nolan Arenado
StL |
3B
Josh Jung
Tex |
| Pre-Season | |
| My Bad | STDS |
|
SP
George Kirby
Sea |
|
| Pre-Season | |
| My Bad | Portland Sea Dogs |
|
OF
Jasson Dominguez
NYA SS Anthony Volpe NYA |
|
| Pre-Season | |
| My Bad | STDS |
|
SS
Ezequiel Tovar
Col |
|
| Week 13 | |
| My Bad | DRIVEWAY DRINKERS |
|
2B
Marcus Semien
Tex SP Carlos Rodon NYA SP Dylan Cease SD |
2B
Ozzie Albies
Atl SP Nick Pivetta Bos RP Jordan Romano Tor |
| Week 16 | |
| My Bad | Whiz Kids |
|
SP
Joe Ryan
Min |
SP
Brady Singer
KC Round 6, 10th Pick (SP Gavin Williams Cle) |
| Week 16 | |
| My Bad | DRIVEWAY DRINKERS |
|
SP
Logan Gilbert
Sea |
Round 4, 11th Pick (2B Jonathan India KC) |