| Week | Add | Drop |
| Pre-Season |
Round 1: SP Max Meyer - Mia Round 2: SS Marco Luciano - SF |
Round 2: SP Brandon Pfaadt - Ari |
| Week 1 |
Round 1: RP Abner Uribe - Mil Round 2: RP Ronel Blanco - Hou |
Round 2: RP Alex Lange - Det |
| Week 2 |
Round 1: SS Jordan Lawlar - Ari Round 2: 3B Trey Lipscomb - Was |
Round 1: SP Shane Bieber - Cle |
| Week 3 |
Round 1: SP Mitch Keller - Pit Round 2: RP David Robertson - Tex |
Round 1: SS Marco Luciano - SF Round 2: 1B Jose Abreu - Hou |
| Week 4 |
Round 1: OF Heston Kjerstad - Bal Round 2: SP Christian Scott - NYN |
Round 2: 3B Trey Lipscomb - Was |
| Week 5 |
Round 1: RP Orion Kerkering - Phi Round 2: RP Yennier Cano - Bal |
Round 1: RP David Robertson - Tex Round 2: RP Abner Uribe - Mil |
| Week 6 |
Round 1: RP Hector Neris - ChN Round 2: SP Kyle Gibson - StL |
Round 1: RP Yennier Cano - Bal Round 2: 1B Joey Meneses - Was |
| Week 7 |
Round 1: OF Blake Perkins - Mil Round 2: C Bo Naylor - Cle |
Round 1: 3B Ezequiel Duran - Tex Round 2: SS Gavin Lux - LAD Round 2: RP Orion Kerkering - Phi |
| Week 8 |
Round 1: SP Tanner Bibee - Cle Round 2: SS Marco Luciano - SF |
Round 1: C Keibert Ruiz - Was Round 2: SP Spencer Turnbull - Phi |
| Week 9 |
Round 1: RP Craig Kimbrel - Bal | |
| Week 10 |
Round 1: OF Masataka Yoshida - Bos Round 2: 3B Elehuris Montero - Col |
Round 1: OF Blake Perkins - Mil Round 2: OF Lars Nootbaar - StL |
| Week 11 |
Round 2: OF Andrew McCutchen - Pit |
Round 2: SP Jesus Luzardo - Mia |
| Week 12 |
Round 1: OF Joey Loperfido - Tor Round 2: SS Miguel Rojas - LAD |
Round 1: SS Marco Luciano - SF Round 2: C Bo Naylor - Cle |
| Week 13 |
Round 1: C Patrick Bailey - SF Round 2: 2B Colt Keith - Det |
Round 1: SP Michael Wacha - KC Round 2: SP Jameson Taillon - ChN |
| Week 14 |
Round 1: 2B Miguel Vargas - ChA Round 2: SS Paul DeJong - KC |
Round 1: 3B Elehuris Montero - Col Round 2: 2B Davis Schneider - Tor |
| Week 15 |
Round 1: 3B Justyn-Henry Malloy - Det Round 1: OF Justyn-Henry Malloy - Det |
Round 1: SS Miguel Rojas - LAD |
| Week 18 |
Round 1: SS Geraldo Perdomo - Ari Round 2: 2B Xavier Edwards - Mia |
Round 1: SS J.P. Crawford - Sea Round 2: SS Geraldo Perdomo - Ari |
| Week 19 |
Round 1: 1B Carlos Santana - Min |
Round 1: SP Kodai Senga - NYN |
| Week 20 |
Round 1: SP Paul Blackburn - NYN Round 2: C Tyler Stephenson - Cin |
Round 1: SP Brayan Bello - Bos Round 2: C Patrick Bailey - SF |
| Week 22 |
Round 1: OF Kerry Carpenter - Det |
Round 1: OF Andrew McCutchen - Pit |
| 1st Team | 2nd Team |
| Pre-Season | |
| Horseheads Buffalos | Ohio Gang |
|
C
Yainer Diaz
Hou |
|
| Pre-Season | |
| Horseheads Buffalos | Bad Reputation |
|
SP
Grayson Rodriguez
Bal |
|
| Pre-Season | |
| Horseheads Buffalos | Bad Reputation |
|
2B
Xander Bogaerts
SD |
|
| Pre-Season | |
| Horseheads Buffalos | Strong Massagy |
|
OF
Eloy Jimenez
Bal |
|
| Week 6 | |
| Horseheads Buffalos | The Summer of George |
|
OF
Corbin Carroll
Ari SP Max Meyer Mia OF Heston Kjerstad Bal 2B Jordan Westburg Bal SS Jordan Lawlar Ari |
1B
Joey Meneses
Was OF Julio Rodriguez Sea RP Jhoan Duran Min 3B Ezequiel Duran Tex OF Lars Nootbaar StL |
| Week 6 | |
| Horseheads Buffalos | Strong Massagy |
|
3B
Josh Jung
Tex 1B Spencer Torkelson Det OF Jordan Walker StL SP Shota Imanaga ChN |
3B
Jose Ramirez
Cle SS Gavin Lux LAD OF Connor Joe Pit 2B Davis Schneider Tor |
| Week 6 | |
| Horseheads Buffalos | Putters Revenge |
|
SP
Bryce Miller
Sea |
1B
Paul Goldschmidt
StL |
| Week 8 | |
| Horseheads Buffalos | Al Davis Junkies |
|
OF
Connor Joe
Pit SS Ezequiel Tovar Col |
SP
Spencer Turnbull
Phi 2B Matt McLain Cin |
| Week 10 | |
| Horseheads Buffalos | Putters Revenge |
|
RP
Craig Kimbrel
Bal |
OF
Seiya Suzuki
ChN |
| Week 12 | |
| Horseheads Buffalos | Putters Revenge |
|
SP
Bobby Miller
LAD SP Bailey Ober Min SP Christian Scott NYN |
SP
Jameson Taillon
ChN SP Michael Wacha KC SS J.P. Crawford Sea |