| Week | Add | Drop |
| Pre-Season |
Round 1: OF Mitch Haniger - Sea Round 2: 3B Curtis Mead - TB Round A: SP Yoshinobu Yamamoto - LAD |
Round 2: SP Matt Manning - Det Round A: 2B Jace Jung - Det |
| Week 1 |
Round 1: SS Oswaldo Cabrera - NYA Round 2: OF Starling Marte - NYN | |
| Week 2 |
Round 1: SP Cody Bradford - Tex Round 2: SP Javier Assad - ChN |
Round 1: SP Shane Bieber - Cle |
| Week 3 |
Round 1: SP Nick Lodolo - Cin Round 2: OF Jurickson Profar - SD |
Round 1: SP Josiah Gray - Was Round 2: 3B Yoan Moncada - ChA |
| Week 4 |
Round 1: SP Jameson Taillon - ChN Round 2: OF Daulton Varsho - Tor |
Round 1: SP Kenta Maeda - Det Round 2: OF James Outman - LAD |
| Week 5 |
Round 1: RP Hector Neris - ChN Round 2: 3B Nick Senzel - Was |
Round 1: SP Eury Perez - Mia Round 2: RP Adbert Alzolay - ChN |
| Week 6 |
Round 2: 3B Curtis Mead - TB |
| 1st Team | 2nd Team |
| Pre-Season | |
| Bottom of the pack 5 | Lehigh Valley Iron Pigs |
|
Round 4, 2nd Pick (OF Lane Thomas Was) Round 6, 2nd Pick (OF Cedric Mullins Bal) |
OF
Dylan Crews
Was 3B Coby Mayo Bal |
| Pre-Season | |
| Bottom of the pack 5 | Dodgers |
|
Round 5, 7th Pick (SP Bailey Ober Min) |
SP
Paul Skenes
Pit |
| Pre-Season | |
| Bottom of the pack 5 | Lehigh Valley Iron Pigs |
|
3B
Manny Machado
SD SS Corey Seager Tex OF Luis Robert ChA Round 7, 2nd Pick (1B Jose Abreu Hou) |
3B
Royce Lewis
Min 1B Triston Casas Bos OF Corbin Carroll Ari |
| Pre-Season | |
| Bottom of the pack 5 | 5 Gamers |
|
SS
Anthony Volpe
NYA |
Round 5, 5th Pick (SS Ha-seong Kim SD) |
| Pre-Season | |
| Bottom of the pack 5 | Pollock's Cuban Stars |
|
3B
Coby Mayo
Bal |
Round 9, 7th Pick (SP Frankie Montas Cin) |
| Pre-Season | |
| Bottom of the pack 5 | Chattanooga Lookouts |
|
OF
Dylan Crews
Was |
Round 6, 8th Pick (2B Jonathan India Cin) |
| Pre-Season | |
| Bottom of the pack 5 | Chattanooga Lookouts |
|
RP
Peter Fairbanks
TB |
Round 2, 8th Pick (RP Adbert Alzolay ChN) |
| Pre-Season | |
| Bottom of the pack 5 | Pollock's Cuban Stars |
|
1B
C.J. Cron
F/A |
Round 5, 7th Pick (SP Bailey Ober Min) |
| Pre-Season | |
| Bottom of the pack 5 | Lehigh Valley Iron Pigs |
|
RP
Edwin Diaz
NYN |
2B
Nolan Gorman
StL |
| Pre-Season | |
| Bottom of the pack 5 | The Plantation |
|
Round 5, 2nd Pick (C Jonah Heim Tex) |
RP
Edwin Diaz
NYN |
| Pre-Season | |
| Bottom of the pack 5 | 5 Gamers |
|
Round 9, 2nd Pick (1B Andrew Vaughn ChA) |
OF
Jasson Dominguez
NYA |
| Pre-Season | |
| Bottom of the pack 5 | Lehigh Valley Iron Pigs |
|
1B
Triston Casas
Bos Round 18, 2nd Pick (C Elias Diaz Col) Round 19, 2nd Pick (RP Will Smith KC) |
Round 2, 3rd Pick (RP Evan Phillips LAD) Round 6, 10th Pick (SP Kodai Senga NYN) |
| Week 4 | |
| Bottom of the pack 5 | Pollock's Cuban Stars |
|
OF
Mike Trout
LAA SP Frankie Montas Cin |
SP
Dylan Cease
SD SP Corbin Burnes Bal |
| Week 7 | |
| Bottom of the pack 5 | Rounding Third |
|
C
Willson Contreras
StL OF Mitch Haniger Sea 3B Nick Senzel Was SP Casey Mize Det OF Corbin Carroll Ari |
OF
Teoscar Hernández
LAD C Sean Murphy Atl SP Joe Ryan Min RP Alexis Diaz Cin RP Robert Suarez SD |
| Week 7 | |
| Bottom of the pack 5 | Lehigh Valley Iron Pigs |
|
RP
Raisel Iglesias
Atl 1B Triston Casas Bos |
SS
C.J. Abrams
Was |