| Week | Add | Drop |
| Pre-Season |
Round 1: OF Tyler Colvin  |
Round 1: C J.R. Towles  |
| Week 1 |
Round 1: OF Mark DeRosa  Round 2: C Ivan Rodriguez  |
Round 1: 2B Blake Dewitt Round 2: OF Andruw Jones  |
| Week 2 |
Round 2: SP David Huff  |
Round 2: OF Tyler Colvin |
| Week 3 |
Round 1: C Rob Johnson  |
Round 1: SP Vicente Padilla  |
| Week 4 |
Round 1: 1B Steven Pearce  Round 2: C Jason Varitek  |
Round 1: SP David Huff Round 2: SP Chris Tillman  |
| Week 5 |
Round 1: OF Aaron Rowand |
Round 1: C Rob Johnson |
| Week 6 |
Round 1: OF Will Venable  Round 2: SP Clayton Richard |
Round 1: OF Mark DeRosa Round 2: SP Randy Wolf  |
| Week 7 |
Round 1: SP Jeff Francis  |
Round 1: C Jason Varitek |
| Week 8 |
Round 1: SP Paul Maholm | |
| Week 9 |
Round 1: SS Yunel Escobar  Round 2: SP Brian Bannister  |
Round 1: OF Will Venable Round 2: SP Jeff Francis |
| Week 10 |
Round 1: OF Angel Pagan  |
Round 1: SP Paul Maholm |
| Week 14 |
Round 1: OF Andres Torres Round 2: SP Doug Fister |
Round 2: SS Cristian Guzman  |
| Week 16 |
Round 1: 3B Miguel Tejada Round 2: SP Randy Wells |
Round 1: SP Brian Bannister Round 2: C Ivan Rodriguez |
| Week 18 |
Round 1: 3B Mike Lowell |
Round 2: SP Randy Wells |
| Week 19 |
Round 1: SP Randy Wolf Round 2: SP Hong-Chih Kuo |
Round 1: 3B Miguel Tejada Round 2: 1B Todd Helton |
| Week 21 |
Round 1: C Rod Barajas |
Round 1: SP Hong-Chih Kuo |
| 1st Team | 2nd Team | Votes |
| Pre-Season | ||
| Stay Frosty | Grand Slam | Decision |
1B
Kendrys Morales
 |
DH
Victor Martinez
 |
Approved 23-0. See Breakdown |
| Week 5 | ||
| Stay Frosty | Bad Reputation | Decision |
RP
Francisco Cordero
 |
SP
C.J. Wilson
|
Approved 19-0. See Breakdown |
| Week 8 | ||
| Stay Frosty | Bad Reputation | Decision |
SP
Derek Lowe
 DH Victor Martinez |
DH
David Ortiz
C Russell Martin SP James Shields  |
Approved 15-0. See Breakdown |