| Quarterback | ||||
|---|---|---|---|---|
| Player | Games | Points | PPG | Stats |
| Brock Purdy | 15 | 310 | 20.66 | 3864 Pass , 323 Rush , 25 TD , 12 Int 3 Fumb |
| Joshua Dobbs | 2 | 36 | 17.92 | 361 Pass , 24 Rush , 4 TD , 2 Int 1 Fumb |
| Brandon Allen | 1 | 11 | 11.46 | 199 Pass , 5 Rush , 1 TD , 1 Int 1 Fumb |
| Running Back | ||||
| Player | Games | Points | PPG | Stats |
| Isaac Guerendo | 10 | 89 | 8.87 | 420 Rush , 152 Receiving , 15 Rec , 4 TD |
| Kyle Juszczyk | 13 | 50 | 3.86 | 27 Rush , 200 Receiving , 19 Rec , 3 TD |
| Christian McCaffrey | 4 | 41 | 10.33 | 202 Rush , 146 Receiving , 15 Rec , 1 Fumb |
| Patrick Taylor | 5 | 28 | 5.66 | 183 Rush , 25 Receiving , 3 Rec , 1 TD |
| Ke'Shawn Vaughn | 1 | 0 | 0.40 | 4 Rush |
| Wide Receiver | ||||
| Player | Games | Points | PPG | Stats |
| Jauan Jennings | 15 | 172 | 11.47 | 975 Receiving , 77 Rec , 6 TD |
| Deebo Samuel | 14 | 129 | 9.22 | 136 Rush , 670 Receiving , 51 Rec , 4 TD , 1 Fumb |
| Demarcus Robinson | 13 | 108 | 8.31 | 505 Receiving , 31 Rec , 7 TD |
| Ricky Pearsall | 8 | 78 | 9.75 | 45 Rush , 400 Receiving , 31 Rec , 3 TD |
| Brandon Aiyuk | 7 | 50 | 7.13 | 374 Receiving , 25 Rec |
| Jacob Cowing | 2 | 11 | 5.35 | 7 Rush , 80 Receiving , 4 Rec |
| Chris Conley | 3 | 11 | 3.53 | 76 Receiving , 6 Rec |
| Ronnie Bell | 2 | 3 | 1.60 | 22 Receiving , 2 Rec |
| Trent Taylor | 1 | 2 | 1.60 | 11 Receiving , 1 Rec |
| Tight End | ||||
| Player | Games | Points | PPG | Stats |
| George Kittle | 15 | 198 | 13.17 | 1106 Receiving , 78 Rec , 8 TD |
| Eric Saubert | 6 | 21 | 3.53 | 97 Receiving , 11 Rec , 1 TD |
| Place Kicker | ||||
| Player | Games | Points | PPG | Stats |
| Jake Moody | 14 | 117 | 8.36 | 14 FG(<40), 6 FG(40-49), 4 FG(50-59), 32 XP, 1 Miss(<40) |
| Defensive Line | ||||
| Player | Games | Points | PPG | Stats |
| Nick Bosa | 13 | 100 | 7.69 | 33 Tackles, 19 Assists, 9.0 Sacks, 1 Int, 1 FF, 1 Fum Rcvy, 1 PD |
| Maliek Collins | 16 | 59 | 3.69 | 20 Tackles, 13 Assists, 5.0 Sacks, 2 Fum Rcvy |
| Sam Okuayinonu | 16 | 51 | 3.19 | 25 Tackles, 10 Assists, 3.0 Sacks, 1 FF, 1 PD |
| Yetur Gross-Matos | 7 | 35 | 5.00 | 14 Tackles, 5 Assists, 4.0 Sacks |
| Evan Anderson | 10 | 34 | 3.40 | 13 Tackles, 11 Assists, 1.0 Sack, 1 FF, 1 Fum Rcvy |
| Kevin Givens | 7 | 25 | 3.57 | 6 Tackles, 5 Assists, 3.5 Sacks |
| Jordan Elliott | 12 | 19 | 1.58 | 12 Tackles, 7 Assists |
| Kalia Davis | 9 | 18 | 2.00 | 6 Tackles, 6 Assists, 1 Int, 1 PD |
| Khalil Davis | 8 | 16 | 2.00 | 7 Tackles, 5 Assists, 1.0 Sack |
| Robert Beal Jr. | 8 | 15 | 1.88 | 9 Tackles, 6 Assists |
| Javon Hargrave | 3 | 11 | 3.67 | 4 Tackles, 3 Assists, 1.0 Sack |
| Nesta Jade | 3 | 8 | 2.67 | 2 Tackles, 6 Assists |
| Alex Barrett | 2 | 2 | 1.00 | 2 Tackles |
| Linebacker | ||||
| Player | Games | Points | PPG | Stats |
| Fred Warner | 17 | 170 | 10.00 | 76 Tackles, 55 Assists, 1.0 Sack, 2 Int, 4 FF, 7 PD |
| De'Vondre Campbell | 13 | 81 | 6.23 | 44 Tackles, 35 Assists, 2 PD |
| Dee Winters | 13 | 49 | 3.77 | 26 Tackles, 19 Assists, 4 PD |
| Tatum Bethune | 4 | 13 | 3.25 | 1 Tackle, 6 Assists, 2 Fum Rcvy |
| Jalen Graham | 5 | 8 | 1.60 | 4 Tackles, 4 Assists |
| Curtis Robinson | 1 | 1 | 1.00 | 1 Tackle |
| Cornerback | ||||
| Player | Games | Points | PPG | Stats |
| Deommodore Lenoir | 15 | 107 | 7.13 | 53 Tackles, 32 Assists, 2 Int, 1 FF, 9 PD |
| Renardo Green | 15 | 82 | 5.47 | 41 Tackles, 20 Assists, 1 Int, 1 FF, 13 PD |
| Isaac Yiadom | 14 | 69 | 4.93 | 37 Tackles, 9 Assists, 1 Int, 2 FF, 2 Fum Rcvy, 6 PD |
| Charvarius Ward | 12 | 61 | 5.08 | 38 Tackles, 16 Assists, 7 PD |
| Nick McCloud | 10 | 26 | 2.60 | 14 Tackles, 11 Assists, 1 PD |
| Darrell Luter | 2 | 6 | 3.00 | 1 Tackle, 2 Assists, 1 FF |
| Rock Ya-Sin | 4 | 5 | 1.25 | 3 Tackles, 2 PD |
| Safety | ||||
| Player | Games | Points | PPG | Stats |
| Ji'Ayir Brown | 17 | 88 | 5.18 | 49 Tackles, 28 Assists, 1 Int, 6 PD |
| Malik Mustapha | 15 | 82 | 5.47 | 32 Tackles, 40 Assists, 1 Int, 5 PD |
| Demetrius Flannigan-Fowles | 9 | 24 | 2.67 | 10 Tackles, 7 Assists, 1 Int, 2 PD |
| George Odum | 7 | 20 | 2.86 | 14 Tackles, 2 Assists, 4 PD |
| Tashaun Gipson | 2 | 7 | 3.50 | 5 Tackles, 1 Assist, 1 PD |
| Jaylen Mahoney | 3 | 3 | 1.00 | 1 Tackle, 2 Assists |