Note: To qualify, non-pitching players must average at least .75 games played per week. This criteria may limit your search results to less than the requested amount (i.e., there may not be enough players at the position requested to fill the amount requested).
| Rank | PPG | Total | Games | Player | Position | Proteam |
| 1. | 30.43 | 517 | 17 | Lamar Jackson | QB | Bal |
| 2. | 27.28 | 464 | 17 | Joe Burrow | QB | Cin |
| 3. | 26.46 | 450 | 17 | Baker Mayfield | QB | TB |
| 4. | 25.71 | 437 | 17 | Josh Allen | QB | Buf |
| 5. | 23.88 | 406 | 17 | Jayden Daniels | QB | Was |
| 6. | 23.75 | 356 | 15 | Jalen Hurts | QB | Phi |
| 7. | 23.41 | 398 | 17 | Jared Goff | QB | Det |
| 8. | 22.47 | 382 | 17 | Sam Darnold | QB | Min |
| 9. | 22.05 | 375 | 17 | Bo Nix | QB | Den |
| 10. | 20.91 | 335 | 16 | Patrick Mahomes | QB | KC |
| 11. | 20.66 | 310 | 15 | Brock Purdy | QB | SF |
| 12. | 20.18 | 343 | 17 | Kyler Murray | QB | Ari |
| 13. | 19.61 | 333 | 17 | Justin Herbert | QB | LAC |
| 14. | 18.92 | 284 | 15 | Jordan Love | QB | GB |
| 15. | 18.50 | 315 | 17 | Aaron Rodgers | QB | NYJ |
| 16. | 18.13 | 308 | 17 | Geno Smith | QB | Sea |
| 17. | 17.58 | 299 | 17 | Caleb Williams | QB | Chi |
| 18. | 16.22 | 227 | 14 | Bryce Young | QB | Car |
| 19. | 16.04 | 257 | 16 | Matthew Stafford | QB | LAR |
| 20. | 15.61 | 265 | 17 | C.J. Stroud | QB | Hou |
| 21. | 15.31 | 214 | 14 | Kirk Cousins | QB | Atl |
| 22. | 0.11 | 2 | 15 | Feleipe Franks | QB | Car |
| 23. | 0.00 | 0 | 14 | Jordan Travis | QB | NYJ |