*=Defensive Player of the Week
| Rank | Score | Week | Proteam | Opponent | Breakdown |
| 1. | 14.00 | Week 09, 2015 | SD | ChiChi | 1 Int, 1 TD, 3 PD |
| 2. | 13.00 | Week 14, 2015 | SD | @KC@KC | 7 Tackles, 1 Int, 1 PD |
| 2. | 13.00 | Week 06, 2014 | SD | @Oak@Oak | 6 Tackles, 1 Int, 2 PD |
| 4. | 12.00 | Week 13, 2020 | SF | BUFBUF | 11 Tackles, 1 PD |
| 5. | 10.00 | Week 06, 2020 | SF | LARLAR | 3 Tackles, 1 Int, 2 PD |
| 5. | 10.00 | Week 13, 2015 | SD | DenDen | 4 Tackles, 1 Int, 1 PD |
| 5. | 10.00 | Week 08, 2015 | SD | @Bal@Bal | 5 Tackles, 2 Assists, 3 PD |
| 8. | 9.00 | Week 17, 2020 | SF | SEASEA | 8 Tackles, 1 Assist |
| 9. | 8.00 | Week 16, 2020 | SF | @ARI@ARI | 6 Tackles, 1 Assist, 1 PD |
| 9. | 8.00 | Week 01, 2016 | SD | @KC@KC | 2 Tackles, 1 Int, 1 PD |
| 11. | 7.00 | Week 14, 2020 | SF | WASWAS | 1 Tackle, 1 Int, 1 PD |
| 11. | 7.00 | Week 04, 2016 | SD | NONO | 6 Tackles, 1 PD |
| 11. | 7.00 | Week 11, 2015 | SD | KCKC | 7 Tackles |
| 14. | 6.00 | Week 08, 2020 | SF | @SEA@SEA | 4 Tackles, 2 Assists |
| 14. | 6.00 | Week 03, 2016 | SD | @Ind@Ind | 2 Tackles, 1 Assist, 1 Fum Rcvy |
| 14. | 6.00 | Week 12, 2015 | SD | @Jac@Jac | 5 Tackles, 1 Assist |
| 17. | 5.00 | Week 01, 2021 | SF | @DET@DET | 3 Tackles, 2 Assists |
| 17. | 5.00 | Week 12, 2020 | SF | @LAR@LAR | 4 Tackles, 1 Assist |
| 17. | 5.00 | Week 15, 2015 | SD | MiaMia | 4 Tackles, 1 PD |
| 17. | 5.00 | Week 01, 2015 | SD | DetDet | 2 Tackles, 2 Assists, 1 PD |
| 17. | 5.00 | Week 02, 2014 | SD | SeaSea | 5 Tackles |
| 17. | 5.00 | Week 01, 2014 | SD | @ARI@ARI | 3 Tackles, 1 Assist, 1 PD |
| 23. | 4.00 | Week 09, 2020 | SF | GBGB | 1 Tackle, 3 Assists |
| 23. | 4.00 | Week 04, 2020 | SF | PHIPHI | 3 Tackles, 1 Assist |
| 23. | 4.00 | Week 05, 2014 | SD | NYJNYJ | 3 Tackles, 1 PD |
| 26. | 3.00 | Week 10, 2020 | SF | @NO@NO | 1 Tackle, 1 Assist, 1 PD |
| 26. | 3.00 | Week 07, 2020 | SF | @NE@NE | 3 Tackles |
| 26. | 3.00 | Week 03, 2020 | SF | @NYG@NYG | 2 Tackles, 1 Assist |
| 26. | 3.00 | Week 02, 2016 | SD | JacJac | 1 Tackle, 1 Assist, 1 PD |
| 26. | 3.00 | Week 05, 2015 | SD | PitPit | 2 Tackles, 1 PD |
| 31. | 2.00 | Week 05, 2020 | SF | MIAMIA | 2 Tackles |
| 32. | 1.00 | Week 01, 2017 | LAC | @Den@Den | 1 Tackle |
| 32. | 1.00 | Week 16, 2015 | SD | @Oak@Oak | 1 Tackle |
| 32. | 1.00 | Week 07, 2015 | SD | OakOak | 1 Tackle |
| 32. | 1.00 | Week 06, 2015 | SD | @GB@GB | 1 Tackle |
| 32. | 1.00 | Week 03, 2015 | SD | @Min@Min | 1 Tackle |
| 32. | 1.00 | Week 02, 2015 | SD | @Cin@Cin | 1 Tackle |
| 32. | 1.00 | Week 08, 2014 | SD | @Den@Den | 1 Tackle |
| 39. | 0.00 | Week 10, 2022 | SF | LACLAC | Played, No Stats |
| 39. | 0.00 | Week 01, 2022 | SF | @CHI@CHI | Played, No Stats |
| 39. | 0.00 | Week 17, 2021 | SF | HOUHOU | Played, No Stats |
| 39. | 0.00 | Week 16, 2021 | SF | @TEN@TEN | Played, No Stats |
| 39. | 0.00 | Week 15, 2021 | SF | ATLATL | Played, No Stats |
| 39. | 0.00 | Week 14, 2021 | SF | @CIN@CIN | Played, No Stats |
| 39. | 0.00 | Week 13, 2021 | SF | @SEA@SEA | Played, No Stats |
| 39. | 0.00 | Week 12, 2021 | SF | MINMIN | Played, No Stats |
| 39. | 0.00 | Week 11, 2021 | SF | @Jac@Jac | Played, No Stats |
| 39. | 0.00 | Week 10, 2021 | SF | LARLAR | Played, No Stats |
| 39. | 0.00 | Week 09, 2021 | SF | ARIARI | Played, No Stats |
| 39. | 0.00 | Week 08, 2021 | SF | @CHI@CHI | Played, No Stats |