*=Defensive Player of the Week
| Rank | Score | Week | Proteam | Opponent | Breakdown |
| 1. | 17.00 | Week 18, 2021 | SF | @LAR@LAR | 4 Tackles, 3 Assists, 2.5 Sacks |
| 2. | 16.00 | Week 15, 2020 | SF | @DAL@DAL | 5 Tackles, 3 Assists, 2.0 Sacks |
| 3. | 14.00 | Week 09, 2021 | SF | ARIARI | 2 Tackles, 8 Assists, 1.0 Sack |
| 4. | 13.00 | Week 12, 2019 | SF | GBGB | 2 Tackles, 3 Assists, 2.0 Sacks |
| 5. | 12.00 | Week 08, 2023 | SF | CinCin | 2 Tackles, 2 Assists, 2.0 Sacks |
| 5. | 12.00 | Week 10, 2019 | SF | SeaSea | 2 Tackles, 1 Assist, 1.5 Sacks, 1 FF |
| 7. | 11.00 | Week 08, 2019 | SF | CarCar | 3 Tackles, 2.0 Sacks |
| 7. | 11.00 | Week 06, 2019 | SF | @LAR@LAR | 3 Tackles, 3 Assists, 0.5 Sack, 1 Fum Rcvy |
| 9. | 10.00 | Week 17, 2021 | SF | HOUHOU | 3 Tackles, 5 Assists, 0.5 Sack |
| 9. | 10.00 | Week 06, 2016 | SF | @Buf@Buf | 3 Tackles, 1.0 Sack, 1 FF |
| 11. | 9.00 | Week 12, 2023 | SF | @Sea@Sea | 2 Tackles, 3 Assists, 1.0 Sack |
| 11. | 9.00 | Week 01, 2019 | SF | @TB@TB | 2 Tackles, 3 Assists, 1.0 Sack |
| 11. | 9.00 | Week 07, 2018 | SF | LARLAR | 5 Tackles, 1.0 Sack |
| 14. | 8.00 | Week 13, 2021 | SF | @SEA@SEA | 2 Tackles, 2 Assists, 1.0 Sack |
| 14. | 8.00 | Week 02, 2020 | SF | @NYJ@NYJ | 1 Tackle, 2 Assists, 1.0 Sack, 1 PD |
| 14. | 8.00 | Week 05, 2017 | SF | @Ind@Ind | 1 Tackle, 4 Assists, 0.5 Sack, 1 PD |
| 14. | 8.00 | Week 02, 2017 | SF | @Sea@Sea | 1 Tackle, 3 Assists, 1.0 Sack |
| 18. | 7.00 | Week 16, 2024 | Jac | @LV @LV | 2 Tack, 1 Ass, 1.00 Sack |
| 18. | 7.00 | Week 11, 2023 | SF | TBTB | 2 Tackles, 1 Assist, 1.0 Sack |
| 18. | 7.00 | Week 04, 2020 | SF | PHIPHI | 4 Tackles, 1 Assist, 0.5 Sack |
| 18. | 7.00 | Week 07, 2019 | SF | @Was@Was | 2 Tackles, 1 Assist, 1.0 Sack |
| 18. | 7.00 | Week 02, 2019 | SF | @Cin@Cin | |
| 18. | 7.00 | Week 08, 2018 | SF | @Ari@Ari | 2 Tackles, 1 Assist, 1.0 Sack |
| 18. | 7.00 | Week 14, 2015 | SF | @Cle@Cle | 3 Tackles, 1.0 Sack |
| 25. | 6.00 | Week 11, 2019 | SF | AriAri | 1 Tackle, 1 Assist, 1.0 Sack |
| 25. | 6.00 | Week 03, 2018 | SF | @KC@KC | 2 Tackles, 1.0 Sack |
| 25. | 6.00 | Week 07, 2016 | SF | TBTB | 3 Tackles, 1 Assist, 0.5 Sack |
| 25. | 6.00 | Week 11, 2015 | SF | @Sea@Sea | 3 Tackles, 3 Assists |
| 25. | 6.00 | Week 03, 2015 | SF | @Ari@Ari | 2 Tackles, 1.0 Sack |
| 30. | 5.00 | Week 01, 2024 | Jac | @Mia@Mia | 1 Tack, 1.00 Sack |
| 30. | 5.00 | Week 10, 2023 | SF | @Jac@Jac | 2 Tackles, 1 Assist, 0.5 Sack |
| 30. | 5.00 | Week 15, 2021 | SF | ATLATL | 5 Tackles |
| 30. | 5.00 | Week 03, 2021 | SF | GBGB | 1 Tackle, 1.0 Sack |
| 30. | 5.00 | Week 16, 2020 | SF | @ARI@ARI | 3 Tackles, 2 Assists |
| 30. | 5.00 | Week 08, 2020 | SF | @SEA@SEA | 4 Tackles, 1 Assist |
| 30. | 5.00 | Week 16, 2019 | SF | LARLAR | 4 Tackles, 1 PD |
| 30. | 5.00 | Week 05, 2019 | SF | CleCle | 3 Tackles, 2 Assists |
| 30. | 5.00 | Week 15, 2018 | SF | SeaSea | 2 Tackles, 3 Assists |
| 30. | 5.00 | Week 04, 2018 | SF | @LAC@LAC | 1 Tackle, 4 Assists |
| 30. | 5.00 | Week 01, 2018 | SF | @Min@Min | 3 Tackles, 2 Assists |
| 30. | 5.00 | Week 01, 2016 | SF | LALA | 1 Tackle, 1.0 Sack |
| 42. | 4.00 | Week 17, 2024 | Jac | TenTen | 3 Ass, 1 PD |
| 42. | 4.00 | Week 05, 2023 | SF | DalDal | 2 Assists, 0.5 Sack |
| 42. | 4.00 | Week 02, 2023 | SF | @LAR@LAR | 3 Tackles, 1 Assist |
| 42. | 4.00 | Week 17, 2022 | SF | @LV@LV | 3 Tackles, 1 Assist |
| 42. | 4.00 | Week 14, 2021 | SF | @CIN@CIN | 3 Tackles, 1 Assist |
| 42. | 4.00 | Week 08, 2021 | SF | @CHI@CHI | 3 Tackles, 1 Assist |
| 42. | 4.00 | Week 07, 2021 | SF | INDIND | 2 Tackles, 2 Assists |
| 42. | 4.00 | Week 04, 2021 | SF | SEASEA | 1 Tackle, 3 Assists |
| 42. | 4.00 | Week 13, 2020 | SF | BUFBUF | 2 Tackles, 2 Assists |