*=Defensive Player of the Week
| Rank | Score | Week | Proteam | Opponent | Breakdown |
| 1. | 23.00 | Week 01, 2023 | Ind | JacJac | 4 Tackles, 3 Assists, 1.0 Sack, 1 TD, 1 FF, 1 Fum Rcvy |
| 2. | 20.00 | Week 05, 2022 * | Ind | @Den@Den | 4 Tackles, 4 Assists, 2.0 Sacks, 1 FF, 1 PD |
| 2. | 20.00 | Week 06, 2016 | SF | @Buf@Buf | 5 Tackles, 4 Assists, 2.0 Sacks, 1 Fum Rcvy |
| 4. | 19.00 | Week 15, 2020 | Ind | HOUHOU | 3 Tackles, 1 Assist, 3.0 Sacks, 1 FF |
| 4. | 19.00 | Week 15, 2018 | SF | SeaSea | 7 Tackles, 4 Assists, 2.0 Sacks |
| 4. | 19.00 | Week 14, 2016 | SF | NYJNYJ | 10 Tackles, 1 Assist, 2.0 Sacks |
| 7. | 18.00 | Week 03, 2019 | SF | PitPit | 7 Tackles, 1 Assist, 1.0 Sack, 1 FF, 1 Fum Rcvy |
| 8. | 17.00 | Week 10, 2019 | SF | SeaSea | 1 Tackle, 4 Assists, 1 TD, 2 Fum Rcvy |
| 8. | 17.00 | Week 01, 2018 | SF | @Min@Min | 3 Tackles, 4 Assists, 2.5 Sacks |
| 10. | 15.00 | Week 13, 2018 | SF | @Sea@Sea | 3 Tackles, 4 Assists, 2.0 Sacks |
| 11. | 14.00 | Week 16, 2022 | Ind | LACLAC | 2 Tackles, 3 Assists, 1.5 Sacks, 1 FF |
| 11. | 14.00 | Week 05, 2019 | SF | CleCle | 4 Tackles, 2 Assists, 1.0 Sack, 1 FF, 1 PD |
| 13. | 13.00 | Week 17, 2020 | Ind | JacJac | 3 Tackles, 1 Assist, 2.0 Sacks, 1 PD |
| 14. | 12.00 | Week 01, 2024 | Ind | HouHou | 5 Tack, 1 Ass, 1.50 Sack |
| 14. | 12.00 | Week 13, 2020 | Ind | @HOU@HOU | 4 Tackles, 2.0 Sacks |
| 14. | 12.00 | Week 15, 2017 | SF | TenTen | 7 Tackles, 2 Assists, 0.5 Sack, 1 PD |
| 17. | 11.00 | Week 13, 2024 | Ind | @NE @NE | 1 Tack, 6 Ass, 1.00 Sack |
| 17. | 11.00 | Week 12, 2024 | Ind | DetDet | 2 Tack, 5 Ass, 1.00 Sack |
| 17. | 11.00 | Week 09, 2022 | Ind | @NE@NE | 4 Tackles, 3 Assists, 1.0 Sack |
| 17. | 11.00 | Week 02, 2020 | Ind | MinMin | 1 Tackle, 2 Assists, 1.5 Sacks, 1 Safety |
| 21. | 10.00 | Week 09, 2024 | Ind | @Min@Min | 4 Tack, 2 Ass, 1.00 Sack |
| 21. | 10.00 | Week 18, 2023 | Ind | HouHou | 1 Tackle, 5 Assists, 1.0 Sack |
| 21. | 10.00 | Week 09, 2023 | Ind | @Car@Car | 4 Tackles, 1.0 Sack, 2 PD |
| 21. | 10.00 | Week 08, 2023 | Ind | NONO | 2 Tackles, 1 Assist, 1.0 Sack, 1 FF |
| 21. | 10.00 | Week 17, 2021 | Ind | LVLV | 4 Tackles, 4 Assists, 0.5 Sack |
| 21. | 10.00 | Week 01, 2021 | Ind | SEASEA | 5 Tackles, 1 Assist, 1.0 Sack |
| 21. | 10.00 | Week 13, 2019 | SF | @Bal@Bal | 4 Tackles, 2 Assists, 1.0 Sack |
| 21. | 10.00 | Week 16, 2018 | SF | ChiChi | 3 Tackles, 1.0 Sack, 1 Fum Rcvy |
| 21. | 10.00 | Week 10, 2016 | SF | @Ari@Ari | 3 Tackles, 1.0 Sack, 1 Fum Rcvy |
| 30. | 9.00 | Week 14, 2023 | Ind | @Cin@Cin | 3 Tackles, 5 Assists, 1 PD |
| 30. | 9.00 | Week 13, 2023 | Ind | @Ten@Ten | 3 Tackles, 3 Assists, 0.5 Sack, 1 PD |
| 30. | 9.00 | Week 06, 2022 | Ind | JacJac | 3 Tackles, 2 Assists, 1.0 Sack |
| 30. | 9.00 | Week 07, 2021 | Ind | @SF@SF | 5 Tackles, 1.0 Sack |
| 30. | 9.00 | Week 06, 2021 | Ind | HOUHOU | 4 Tackles, 1 Assist, 1.0 Sack |
| 30. | 9.00 | Week 06, 2020 | Ind | CINCIN | 4 Tackles, 1 Assist, 1.0 Sack |
| 30. | 9.00 | Week 12, 2018 | SF | @TB@TB | 5 Tackles, 1.0 Sack |
| 30. | 9.00 | Week 02, 2018 | SF | DetDet | 5 Tackles, 1.0 Sack |
| 30. | 9.00 | Week 04, 2017 | SF | @Ari@Ari | 4 Tackles, 1.0 Sack, 1 PD |
| 39. | 8.00 | Week 10, 2024 | Ind | BufBuf | 3 Tack, 5 Ass |
| 39. | 8.00 | Week 17, 2023 | Ind | LVLV | 3 Tackles, 1 Assist, 1.0 Sack |
| 39. | 8.00 | Week 10, 2023 | Ind | @NE@NE | 4 Tackles, 4 Assists |
| 39. | 8.00 | Week 02, 2023 | Ind | @Hou@Hou | 4 Tackles, 1.0 Sack |
| 39. | 8.00 | Week 15, 2022 | Ind | @Min@Min | 2 Tackles, 1 Assist, 1.0 Sack, 1 PD |
| 39. | 8.00 | Week 10, 2022 | Ind | @LV@LV | 3 Tackles, 2 Assists, 0.5 Sack, 1 PD |
| 39. | 8.00 | Week 15, 2021 | Ind | NENE | 3 Tackles, 1 Assist, 1.0 Sack |
| 39. | 8.00 | Week 12, 2021 | Ind | TBTB | 3 Tackles, 1.0 Sack, 1 PD |
| 39. | 8.00 | Week 09, 2020 | Ind | BALBAL | 2 Tackles, 3 Assists, 1 FF |
| 39. | 8.00 | Week 17, 2019 | SF | @Sea@Sea | 2 Tackles, 2 Assists, 1.0 Sack |
| 39. | 8.00 | Week 09, 2019 | SF | @Ari@Ari | 3 Tackles, 1 Assist, 1.0 Sack |
| 39. | 8.00 | Week 10, 2018 | SF | NYGNYG | 4 Assists, 0.5 Sack, 2 PD |