*=Defensive Player of the Week
| Rank | Score | Week | Proteam | Opponent | Breakdown |
| 1. | 17.00 | Week 14, 2021 | Pit | @MIN@MIN | 4 Tackles, 2 Int, 3 PD |
| 2. | 16.00 | Week 01, 2019 | SF | @TB@TB | 2 Tackles, 1 Int, 1 TD, 3 PD |
| 3. | 14.00 | Week 01, 2022 | Pit | @CIN@CIN | 6 Tackles, 2 Assists, 1 Int, 1 PD |
| 4. | 13.00 | Week 17, 2024 | LAR | AriAri | 5 Tack, 1 Ass, 1 Int, 2 PD |
| 4. | 13.00 | Week 16, 2020 | SF | @ARI@ARI | 7 Tackles, 1 Int, 1 PD |
| 6. | 10.00 | Week 14, 2023 | LAR | @Bal@Bal | 4 Tackles, 1 Int, 1 PD |
| 6. | 10.00 | Week 05, 2023 | LAR | PhiPhi | 4 Tackles, 1 Int, 1 PD |
| 6. | 10.00 | Week 16, 2017 | SF | JacJac | 2 Tackles, 1 Assist, 1 Int, 2 PD |
| 9. | 9.00 | Week 08, 2017 | SF | @Phi@Phi | 3 Tackles, 1 Int, 1 PD |
| 10. | 8.00 | Week 15, 2024 | LAR | @SF @SF | 4 Tack, 1 Ass, 3 PD |
| 10. | 8.00 | Week 17, 2023 | LAR | @NYG@NYG | 4 Tackles, 3 Assists, 1 PD |
| 10. | 8.00 | Week 09, 2023 | LAR | @GB@GB | 3 Tackles, 1 Assist, 1 Fum Rcvy, 1 PD |
| 10. | 8.00 | Week 17, 2021 | Pit | CLECLE | 1 Int, 3 PD |
| 10. | 8.00 | Week 17, 2017 | SF | @LAR@LAR | 4 Tackles, 1 FF, 1 PD |
| 15. | 7.00 | Week 17, 2019 | SF | @Sea@Sea | 5 Tackles, 2 PD |
| 15. | 7.00 | Week 02, 2019 | SF | @Cin@Cin | |
| 17. | 6.00 | Week 16, 2024 | LAR | @NYJ@NYJ | 5 Tack, 1 PD |
| 17. | 6.00 | Week 03, 2023 | LAR | @Cin@Cin | 1 Int, 1 PD |
| 17. | 6.00 | Week 03, 2022 | Pit | @Cle@Cle | 4 Tackles, 1 Assist, 1 PD |
| 17. | 6.00 | Week 13, 2021 | Pit | BALBAL | 5 Tackles, 1 PD |
| 17. | 6.00 | Week 14, 2019 | SF | @NO@NO | 4 Tackles, 1 Assist, 1 PD |
| 22. | 5.00 | Week 18, 2023 | LAR | @SF@SF | 3 Tackles, 2 Assists |
| 22. | 5.00 | Week 16, 2023 | LAR | NONO | |
| 22. | 5.00 | Week 13, 2023 | LAR | CleCle | 4 Tackles, 1 PD |
| 22. | 5.00 | Week 12, 2023 | LAR | @Ari@Ari | 2 Tackles, 3 PD |
| 22. | 5.00 | Week 06, 2023 | LAR | AriAri | 3 Tackles, 2 PD |
| 22. | 5.00 | Week 04, 2023 | LAR | @Ind@Ind | 1 Tackle, 1 Fum Rcvy, 1 PD |
| 22. | 5.00 | Week 08, 2022 | Pit | @Phi@Phi | 5 Tackles |
| 22. | 5.00 | Week 02, 2020 | SF | @NYJ@NYJ | 3 Tackles, 2 Assists |
| 22. | 5.00 | Week 13, 2018 | SF | @Sea@Sea | 4 Tackles, 1 PD |
| 22. | 5.00 | Week 03, 2018 | SF | @KC@KC | 5 Tackles |
| 22. | 5.00 | Week 01, 2018 | SF | @Min@Min | 1 Assist, 1 Fum Rcvy, 1 PD |
| 33. | 4.00 | Week 08, 2023 | LAR | @Dal@Dal | 3 Tackles, 1 PD |
| 33. | 4.00 | Week 07, 2023 | LAR | PitPit | 3 Tackles, 1 Assist |
| 33. | 4.00 | Week 15, 2019 | SF | AtlAtl | 3 Tackles, 1 Assist |
| 33. | 4.00 | Week 14, 2018 | SF | DenDen | 1 Tackle, 3 Assists |
| 33. | 4.00 | Week 12, 2018 | SF | @TB@TB | 4 Tackles |
| 33. | 4.00 | Week 10, 2018 | SF | NYGNYG | 2 Tackles, 1 Assist, 1 PD |
| 33. | 4.00 | Week 04, 2018 | SF | @LAC@LAC | 4 Tackles |
| 33. | 4.00 | Week 02, 2018 | SF | DetDet | 3 Tackles, 1 Assist |
| 33. | 4.00 | Week 15, 2017 | SF | TenTen | 3 Tackles, 1 PD |
| 33. | 4.00 | Week 10, 2017 | SF | NYGNYG | 3 Tackles, 1 PD |
| 33. | 4.00 | Week 09, 2017 | SF | AriAri | 3 Tackles, 1 Assist |
| 44. | 3.00 | Week 18, 2024 | LAR | SeaSea | 2 Tack, 1 PD |
| 44. | 3.00 | Week 11, 2024 | LAR | @NE @NE | 2 Tack, 1 Ass |
| 44. | 3.00 | Week 09, 2024 | LAR | @Sea@Sea | 1 Tack, 2 Ass |
| 44. | 3.00 | Week 07, 2024 | LAR | LV LV | 2 Tack, 1 PD |
| 44. | 3.00 | Week 05, 2024 | LAR | GB GB | 3 Tack |
| 44. | 3.00 | Week 15, 2020 | SF | @DAL@DAL | 1 Tackle, 2 PD |
| 44. | 3.00 | Week 05, 2020 | SF | MIAMIA | 2 Tackles, 1 Assist |