*=Offensive Player of the Week
| Rank | Score | Week | Proteam | Opponent | Breakdown |
| 1. | 24.00 | Week 16, 2023 | Pit | CinCin | |
| 2. | 22.70 | Week 17, 2020 | Pit | @CLE@CLE | 315 Pass, 1 Rush, 2 TD, 1 Int |
| 3. | 22.06 | Week 04, 2019 | Pit | CinCin | 229 Pass, - 3 Rush, 7 Receiving, 1 Rec, 2 TD |
| 4. | 21.54 | Week 08, 2024 | Ten | @Det@Det | 266 Pass, 29 Rush, 2 TD, 2 Int |
| 5. | 21.50 | Week 09, 2024 | Ten | NE NE | 240 Pass, 19 Rush, 2 TD, 1 Int |
| 6. | 20.04 | Week 08, 2019 | Pit | MiaMia | 251 Pass, 2 TD, 1 Int |
| 7. | 19.76 | Week 15, 2024 | Ten | CinCin | 209 Pass, 14 Rush, 2 TD, 1 Int |
| 8. | 18.46 | Week 03, 2019 | Pit | @SF@SF | 174 Pass, 15 Rush, 2 TD, 1 Int |
| 9. | 18.38 | Week 16, 2024 | Ten | @Ind@Ind | 252 Pass, 3 Rush, 2 TD, 3 Int, 1 2-Pt |
| 10. | 17.28 | Week 10, 2021 | Pit | DETDET | 242 Pass, 36 Rush, 1 TD, 1 Int |
| 11. | 15.58 | Week 10, 2019 | Pit | LARLAR | 242 Pass, - 1 Rush, 1 TD |
| 12. | 15.18 | Week 02, 2019 | Pit | SeaSea | |
| 13. | 14.02 | Week 17, 2024 | Ten | @Jac@Jac | 193 Pass, 23 Rush, 1 TD, 1 Int |
| 14. | 12.90 | Week 07, 2024 | Ten | @Buf@Buf | 215 Pass, 13 Rush, 1 TD, 1 Int, 1 Fumb |
| 15. | 12.14 | Week 09, 2019 | Pit | IndInd | 191 Pass, 5 Rush, 1 TD, 1 Int |
| 16. | 11.46 | Week 17, 2023 | Pit | @Sea@Sea | 274 Pass, 5 Rush |
| 17. | 11.24 | Week 05, 2019 | Pit | BalBal | 131 Pass, 1 TD |
| 18. | 11.16 | Week 16, 2019 | Pit | @NYJ@NYJ | 129 Pass, 1 TD |
| 19. | 10.98 | Week 11, 2025 | Pit | CinCin | 127 Pass, -1 Rush, 1 TD |
| 19. | 10.98 | Week 18, 2023 | Pit | @Bal@Bal | 152 Pass, -1 Rush, 1 TD, 1 Fumb |
| 21. | 10.54 | Week 12, 2025 | Pit | @Chi@Chi | 171 Pass, 7 Rush, 1 TD, 1 Int, 1 Fumb |
| 22. | 8.34 | Week 11, 2019 | Pit | @Cle@Cle | 221 Pass, 15 Rush, 1 TD, 4 Int |
| 23. | 3.40 | Week 04, 2024 | Ten | @Mia@Mia | 85 Pass |
| 24. | 3.30 | Week 18, 2024 | Ten | HouHou | 70 Pass, 5 Rush |
| 25. | 3.10 | Week 16, 2021 | Pit | @KC@KC | 35 Pass, 17 Rush |
| 26. | 1.90 | Week 12, 2019 | Pit | @Cin@Cin | 85 Pass, 5 Rush, 1 Int |
| 27. | 0.48 | Week 02, 2025 | Pit | SeaSea | 12 Pass |
| 28. | 0.12 | Week 15, 2023 | Pit | @Ind@Ind | 3 Pass |
| 28. | 0.12 | Week 09, 2020 | Pit | @DAL@DAL | 3 Pass |
| 30. | 0.00 | Week 06, 2025 | Pit | CleCle | |
| 30. | 0.00 | Week 12, 2024 | Ten | @Hou@Hou | |
| 30. | 0.00 | Week 14, 2023 | Pit | NENE | Played, No Stats |
| 30. | 0.00 | Week 02, 2023 | Pit | CleCle | Played, No Stats |
| 30. | 0.00 | Week 10, 2020 | Pit | CINCIN | Played, No Stats |
| 35. | -0.06 | Week 06, 2020 | Pit | CLECLE | 6 Pass, - 3 Rush |
| 36. | -0.40 | Week 11, 2020 | Pit | @Jac@Jac | - 4 Rush |
| 37. | -2.00 | Week 13, 2025 | Pit | BufBuf | 1 Int |