*=Defensive Player of the Week
| Rank | Score | Week | Proteam | Opponent | Breakdown |
| 1. | 20.00 | Week 10, 2024 | Buf | @Ind@Ind | 3 Tack, 1.00 Sack, 1 Int, 1 TD, 2 PD |
| 2. | 19.00 | Week 14, 2020 | Buf | PITPIT | 4 Tackles, 3 Assists, 1 Int, 1 PD |
| 3. | 16.00 | Week 06, 2023 | Buf | NYGNYG | 9 Tackles, 6 Assists, 1 PD |
| 3. | 16.00 | Week 10, 2020 | Buf | @ARI@ARI | 8 Tackles, 1 Assist, 1.0 Sack, 1 FF |
| 5. | 14.00 | Week 06, 2024 | Buf | @NYJ@NYJ | 4 Tack, 4 Ass, 1 Int, 1 PD |
| 6. | 13.00 | Week 14, 2023 | Buf | @KC@KC | 6 Tackles, 3 Assists, 1 Fum Rcvy, 1 PD |
| 6. | 13.00 | Week 05, 2021 | Buf | @KC@KC | 8 Tackles, 4 Assists, 1 PD |
| 6. | 13.00 | Week 02, 2021 | Buf | @MIA@MIA | 3 Tackles, 1 Assist, 1.0 Sack, 1 FF, 2 PD |
| 9. | 12.00 | Week 16, 2024 | Buf | NE NE | 1 Tack, 2 Ass, 1 TD, 1 Fum Rcvy |
| 9. | 12.00 | Week 06, 2022 | Buf | @KC@KC | 4 Tackles, 2 Assists, 1 Int, 1 PD |
| 9. | 12.00 | Week 04, 2018 | Buf | @GB@GB | 4 Tackles, 1 Assist, 1.0 Sack, 1 FF |
| 12. | 11.00 | Week 03, 2020 | Buf | LARLAR | 10 Tackles, 1 Assist |
| 13. | 10.00 | Week 10, 2023 | Buf | DenDen | 5 Tackles, 2 Assists, 1 FF |
| 13. | 10.00 | Week 08, 2023 | Buf | TBTB | 4 Tackles, 2 Assists, 1.0 Sack |
| 13. | 10.00 | Week 01, 2022 | Buf | @LAR@LAR | 5 Tackles, 4 Assists, 1 PD |
| 13. | 10.00 | Week 10, 2021 | Buf | @NYJ@NYJ | 4 Tackles, 1 Int, 1 PD |
| 13. | 10.00 | Week 13, 2019 | Buf | @Dal@Dal | 7 Tackles, 2 Assists, 1 PD |
| 13. | 10.00 | Week 08, 2019 | Buf | PhiPhi | 2 Tackles, 1 Assist, 1.0 Sack, 1 FF |
| 13. | 10.00 | Week 05, 2018 | Buf | TenTen | 4 Tackles, 1 Int, 1 PD |
| 20. | 9.00 | Week 15, 2024 | Buf | @Det@Det | 5 Tack, 3 Ass, 1 PD |
| 20. | 9.00 | Week 18, 2023 | Buf | @Mia@Mia | 4 Tackles, 5 Assists |
| 20. | 9.00 | Week 16, 2023 | Buf | @LAC@LAC | |
| 20. | 9.00 | Week 18, 2022 | Buf | NENE | 6 Tackles, 2 Assists, 1 PD |
| 20. | 9.00 | Week 14, 2022 | Buf | NYJNYJ | 7 Tackles, 1 Assist, 1 PD |
| 20. | 9.00 | Week 05, 2022 | Buf | PitPit | 5 Tackles, 1 Fum Rcvy, 1 PD |
| 20. | 9.00 | Week 01, 2021 | Buf | PITPIT | 7 Tackles, 2 PD |
| 27. | 8.00 | Week 08, 2024 | Buf | @Sea@Sea | 4 Tack, 4 Ass |
| 27. | 8.00 | Week 07, 2024 | Buf | TenTen | 4 Tack, 3 Ass, 1 PD |
| 27. | 8.00 | Week 15, 2023 | Buf | DalDal | 7 Tackles, 1 PD |
| 27. | 8.00 | Week 04, 2023 | Buf | MiaMia | 3 Tackles, 1 Assist, 1 FF, 1 PD |
| 27. | 8.00 | Week 03, 2023 | Buf | @Was@Was | 4 Tackles, 1 Assist, 1 FF |
| 27. | 8.00 | Week 11, 2022 | Buf | CleCle | 4 Tackles, 4 Assists |
| 27. | 8.00 | Week 17, 2021 | Buf | ATLATL | 3 Tackles, 1 Assist, 1.0 Sack |
| 27. | 8.00 | Week 15, 2021 | Buf | CARCAR | 3 Tackles, 1 Assist, 1.0 Sack |
| 27. | 8.00 | Week 12, 2020 | Buf | LACLAC | 3 Tackles, 3 Assists, 2 PD |
| 27. | 8.00 | Week 06, 2020 | Buf | KCKC | 8 Tackles |
| 27. | 8.00 | Week 03, 2018 | Buf | @Min@Min | 5 Tackles, 2 Assists, 1 PD |
| 38. | 7.00 | Week 14, 2024 | Buf | @LAR@LAR | 6 Tack, 1 Ass |
| 38. | 7.00 | Week 09, 2024 | Buf | MiaMia | 3 Tack, 1 Ass, 1 FF |
| 38. | 7.00 | Week 08, 2022 | Buf | GBGB | 6 Tackles, 1 Assist |
| 38. | 7.00 | Week 17, 2020 | Buf | MIAMIA | 3 Tackles, 3 Assists, 1 PD |
| 38. | 7.00 | Week 05, 2020 | Buf | @TEN@TEN | 5 Tackles, 2 Assists |
| 38. | 7.00 | Week 04, 2020 | Buf | @LV@LV | 5 Tackles, 2 Assists |
| 38. | 7.00 | Week 07, 2018 | Buf | @Ind@Ind | 7 Tackles |
| 45. | 6.00 | Week 13, 2024 | Buf | SF SF | 4 Tack, 2 Ass |
| 45. | 6.00 | Week 11, 2024 | Buf | KC KC | 4 Tack, 2 Ass |
| 45. | 6.00 | Week 12, 2023 | Buf | @Phi@Phi | 5 Tackles, 1 Assist |
| 45. | 6.00 | Week 13, 2022 | Buf | @NE@NE | 3 Tackles, 1 Assist, 2 PD |
| 45. | 6.00 | Week 10, 2022 | Buf | MinMin | 5 Tackles, 1 Assist |
| 45. | 6.00 | Week 09, 2022 | Buf | @NYJ@NYJ | 3 Tackles, 2 Assists, 1 PD |