*=Offensive Player of the Week
| Rank | Score | Week | Proteam | Opponent | Breakdown |
| 1. | 45.00 | Week 13, 2017 * | KC | @NYJ@NYJ | 366 Pass, 70 Rush, 4 TD |
| 2. | 41.00 | Week 15, 2013 | KC | @Oak@Oak | 287 Pass, 17 Rush, 5 TD, 1 Fumb |
| 3. | 38.00 | Week 01, 2017 | KC | @NE@NE | 368 Pass, 3 Rush, 4 TD |
| 4. | 34.00 | Week 05, 2012 | SF | BufBuf | 303 Pass, 49 Rush, 3 TD |
| 5. | 31.00 | Week 07, 2017 | KC | @Oak@Oak | 342 Pass, 3 TD |
| 5. | 31.00 | Week 05, 2017 | KC | @Hou@Hou | 324 Pass, 19 Rush, 3 TD |
| 5. | 31.00 | Week 01, 2016 | KC | SDSD | 363 Pass, 15 Rush, 3 TD, 1 Int |
| 8. | 30.00 | Week 08, 2015 | KC | DetDet | 145 Pass, 78 Rush, 3 TD |
| 9. | 29.00 | Week 14, 2010 | SF | SeaSea | 255 Pass, 12 Rush, 3 TD |
| 10. | 28.00 | Week 04, 2017 | KC | WasWas | 293 Pass, 56 Rush, 2 TD |
| 10. | 28.00 | Week 17, 2016 | KC | @SD@SD | 264 Pass, 21 Rush, 3 TD, 1 Int |
| 10. | 28.00 | Week 13, 2015 | KC | @Oak@Oak | 162 Pass, 23 Rush, 3 TD, 1 2-Pt |
| 10. | 28.00 | Week 01, 2015 | KC | @Hou@Hou | 243 Pass, 15 Rush, 3 TD |
| 10. | 28.00 | Week 04, 2013 | KC | NYGNYG | 288 Pass, 37 Rush, 3 TD, 2 Int |
| 15. | 27.00 | Week 04, 2014 | KC | NENE | 248 Pass, 8 Rush, 3 TD |
| 15. | 27.00 | Week 12, 2013 | KC | SDSD | 294 Pass, - 3 Rush, 3 TD, 1 Int |
| 15. | 27.00 | Week 08, 2012 | SF | @Ari@Ari | 232 Pass, 6 Rush, 3 TD |
| 15. | 27.00 | Week 15, 2006 | SF | @Sea@Sea | 162 Pass, 33 Rush, 3 TD |
| 19. | 26.00 | Week 11, 2013 | KC | @Den@Den | 230 Pass, 52 Rush, 2 TD |
| 19. | 26.00 | Week 05, 2010 | SF | PhiPhi | 309 Pass, 16 Rush, 3 TD, 2 Int, 1 Fumb |
| 21. | 25.00 | Week 12, 2015 | KC | BufBuf | 255 Pass, 35 Rush, 2 TD |
| 21. | 25.00 | Week 03, 2014 | KC | @Mia@Mia | 186 Pass, 17 Rush, 3 TD, 1 Fumb |
| 21. | 25.00 | Week 13, 2013 | KC | DenDen | 293 Pass, 46 Rush, 2 TD, 1 Int |
| 21. | 25.00 | Week 08, 2013 | KC | CleCle | 225 Pass, 40 Rush, 2 TD |
| 21. | 25.00 | Week 02, 2013 | KC | DalDal | 223 Pass, 57 Rush, 2 TD |
| 21. | 25.00 | Week 11, 2009 | SF | @GB@GB | 227 Pass, 2 Rush, 3 TD, 1 Int |
| 21. | 25.00 | Week 07, 2009 | SF | @Hou@Hou | 206 Pass, 16 Rush, 3 TD, 1 Int |
| 28. | 24.00 | Week 15, 2014 | KC | OakOak | 297 Pass, 17 Rush, 2 TD |
| 28. | 24.00 | Week 05, 2011 | SF | TBTB | 170 Pass, 3 TD |
| 28. | 24.00 | Week 13, 2009 | SF | @Sea@Sea | 310 Pass, 1 Rush, 2 TD |
| 31. | 23.60 | Week 01, 2018 | Was | @Ari@Ari | 255 Pass, 14 Rush, 2 TD |
| 32. | 23.00 | Week 16, 2016 | KC | DenDen | 244 Pass, 46 Rush, 2 TD, 1 Int |
| 32. | 23.00 | Week 13, 2011 | SF | StLStL | 274 Pass, 10 Rush, 2 TD |
| 32. | 23.00 | Week 17, 2010 | SF | AriAri | 276 Pass, - 1 Rush, 2 TD |
| 32. | 23.00 | Week 05, 2006 | SF | OakOak | 165 Pass, 10 Rush, 3 TD, 1 Int |
| 36. | 22.00 | Week 15, 2017 | KC | LACLAC | 231 Pass, 13 Rush, 2 TD |
| 36. | 22.00 | Week 04, 2011 | SF | @Phi@Phi | 291 Pass, - 1 Rush, 2 TD, 1 Fumb |
| 38. | 21.00 | Week 09, 2017 | KC | @Dal@Dal | 263 Pass, 19 Rush, 2 TD, 1 Int |
| 38. | 21.00 | Week 11, 2016 | KC | TBTB | 261 Pass, 10 Rush, 2 TD, 1 Int |
| 38. | 21.00 | Week 04, 2016 | KC | @Pit@Pit | 287 Pass, 2 Rush, 2 TD, 1 Int |
| 38. | 21.00 | Week 12, 2014 | KC | @Oak@Oak | 234 Pass, 5 Rush, 2 TD |
| 38. | 21.00 | Week 02, 2012 | SF | DetDet | 226 Pass, 7 Rush, 2 TD |
| 38. | 21.00 | Week 01, 2012 | SF | @GB@GB | 211 Pass, 13 Rush, 2 TD |
| 38. | 21.00 | Week 11, 2011 | SF | AriAri | 267 Pass, 17 Rush, 2 TD, 1 Int |
| 38. | 21.00 | Week 12, 2009 | SF | JacJac | 232 Pass, 8 Rush, 2 TD |
| 46. | 20.80 | Week 03, 2018 | Was | GBGB | 220 Pass, 20 Rush, 2 TD, 1 Int |
| 47. | 20.00 | Week 07, 2016 | KC | NONO | 214 Pass, 7 Rush, 2 TD |
| 47. | 20.00 | Week 17, 2015 | KC | OakOak | 156 Pass, 61 Rush, 2 TD, 2 Int |
| 47. | 20.00 | Week 16, 2015 | KC | CleCle | 125 Pass, 54 Rush, 2 TD, 1 Int |
| 47. | 20.00 | Week 03, 2015 | KC | @GB@GB | 290 Pass, 33 Rush, 1 TD, 1 Int, 1 2-Pt |