*=Defensive Player of the Week
| Rank | Score | Week | Proteam | Opponent | Breakdown |
| 1. | 14.00 | Week 11, 2014 | SF | @NYG@NYG | 5 Tackles, 2 Assists, 1.0 Sack, 1 FF |
| 2. | 13.00 | Week 07, 2010 | SF | @Car@Car | 1 Tackle, 1 Int, 1 TD, 1 PD |
| 3. | 12.00 | Week 15, 2012 | SF | @NE@NE | 4 Tackles, 2.0 Sacks |
| 4. | 11.00 | Week 16, 2011 | SF | @Sea@Sea | 3 Tackles, 4 Assists, 1.0 Sack |
| 5. | 10.00 | Week 13, 2011 | SF | StLStL | 3 Tackles, 1.0 Sack, 1 FF |
| 5. | 10.00 | Week 01, 2011 | SF | SeaSea | 6 Tackles, 1.0 Sack |
| 5. | 10.00 | Week 04, 2009 | SF | StLStL | 1 Tackle, 1 TD, 1 Fum Rcvy |
| 8. | 9.00 | Week 05, 2008 | SF | NENE | 3 Tackles, 1 Assist, 1.0 Sack, 1 PD |
| 9. | 8.00 | Week 15, 2014 | SF | @Sea@Sea | 3 Tackles, 1 Assist, 1.0 Sack |
| 9. | 8.00 | Week 14, 2013 | SF | SeaSea | 4 Tackles, 1.0 Sack |
| 11. | 7.00 | Week 05, 2013 | SF | HouHou | 3 Tackles, 1.0 Sack |
| 11. | 7.00 | Week 02, 2013 | SF | @Sea@Sea | 3 Tackles, 4 Assists |
| 11. | 7.00 | Week 15, 2011 | SF | PitPit | 1 Tackle, 1 Assist, 0.5 Sack, 1 FF |
| 11. | 7.00 | Week 12, 2011 | SF | @Bal@Bal | 5 Tackles, 2 Assists |
| 15. | 6.00 | Week 12, 2014 | SF | WasWas | 2 Tackles, 1.0 Sack |
| 15. | 6.00 | Week 01, 2013 | SF | GBGB | 2 Tackles, 2 Assists, 0.5 Sack |
| 15. | 6.00 | Week 11, 2012 | SF | ChiChi | 4 Tackles, 1 Safety |
| 15. | 6.00 | Week 02, 2012 | SF | DetDet | 2 Tackles, 1.0 Sack |
| 15. | 6.00 | Week 06, 2011 | SF | @Det@Det | 1 Tackle, 1 Assist, 0.5 Sack, 2 PD |
| 15. | 6.00 | Week 02, 2009 | SF | SeaSea | |
| 15. | 6.00 | Week 01, 2009 | SF | @Ari@Ari | 2 Tackles, 1.0 Sack |
| 15. | 6.00 | Week 02, 2008 | SF | @Sea@Sea | 4 Tackles, 1 Assist, 1 PD |
| 23. | 5.00 | Week 13, 2013 | SF | StLStL | 1 Tackle, 1.0 Sack |
| 23. | 5.00 | Week 17, 2012 | SF | AriAri | 2 Tackles, 1 FF |
| 23. | 5.00 | Week 16, 2012 | SF | @Sea@Sea | 1 Tackle, 4 Assists |
| 23. | 5.00 | Week 14, 2011 | SF | @Ari@Ari | 2 Tackles, 1 Fum Rcvy |
| 23. | 5.00 | Week 02, 2011 | SF | DalDal | 1 Tackle, 1.0 Sack |
| 23. | 5.00 | Week 08, 2009 | SF | @Ind@Ind | 1 Tackle, 1.0 Sack |
| 23. | 5.00 | Week 04, 2008 | SF | @NO@NO | 3 Tackles, 1 Assist, 1 PD |
| 23. | 5.00 | Week 16, 2007 | SF | TBTB | 1 Tackle, 1.0 Sack |
| 31. | 4.00 | Week 06, 2014 | SF | @Stl@Stl | 2 Tackles, 2 Assists |
| 31. | 4.00 | Week 04, 2014 | SF | PhiPhi | 3 Tackles, 1 Assist |
| 31. | 4.00 | Week 03, 2013 | SF | IndInd | 4 Tackles |
| 31. | 4.00 | Week 01, 2012 | SF | @GB@GB | 3 Tackles, 1 Assist |
| 31. | 4.00 | Week 15, 2010 | SF | @SD@SD | 3 Tackles, 1 Assist |
| 36. | 3.00 | Week 10, 2014 | SF | @NO@NO | 2 Tackles, 1 Assist |
| 36. | 3.00 | Week 09, 2014 | SF | StlStl | 1 Tackle, 2 Assists |
| 36. | 3.00 | Week 03, 2014 | SF | @Ari@Ari | 2 Tackles, 1 Assist |
| 36. | 3.00 | Week 01, 2014 | SF | @DAL@DAL | 3 Tackles |
| 36. | 3.00 | Week 17, 2013 | SF | @Ari@Ari | 3 Tackles |
| 36. | 3.00 | Week 08, 2013 | SF | @Jac@Jac | 3 Tackles |
| 36. | 3.00 | Week 10, 2012 | SF | StLStL | 3 Tackles |
| 36. | 3.00 | Week 08, 2012 | SF | @Ari@Ari | 3 Tackles |
| 36. | 3.00 | Week 04, 2012 | SF | @NYJ@NYJ | 1 Tackle, 1 Assist, 1 PD |
| 36. | 3.00 | Week 10, 2011 | SF | NYGNYG | 3 Tackles |
| 36. | 3.00 | Week 04, 2011 | SF | @Phi@Phi | 1 Assist, 0.5 Sack |
| 36. | 3.00 | Week 16, 2010 | SF | @StL@StL | 2 Tackles, 1 Assist |
| 36. | 3.00 | Week 12, 2009 | SF | JacJac | 1 Fum Rcvy |
| 36. | 3.00 | Week 17, 2008 | SF | WasWas | 2 Tackles, 1 Assist |
| 36. | 3.00 | Week 13, 2008 | SF | @Buf@Buf | 1 Tackle, 1 Assist, 1 PD |