| Position | Starters | Team | Games | Opponents |
| C | Ivan Herrera | StL | 9 | @Cin(5) NYN(4) |
| 1B | Josh Naylor | Ari | 6 | @NYN(3) @Phi(3) |
| 2B | Nolan Gorman | StL | 9 | @Cin(5) NYN(4) |
| SS | CJ Abrams | Was | 7 | NYN(1) @Phi(3) @Cin(3) |
| 3B | Josh Jung | Tex | 7 | Oak(4) Sea(3) |
| OF | Bryan Reynolds | Pit | 6 | ChN(3) SD(3) |
| OF | TJ Friedl | Cin | 8 | StL(5) Was(3) |
| OF | Julio Rodriguez | Sea | 5 | LAA(2) @Tex(3) |
| DH (OF) | Adolis Garcia | Tex | 7 | Oak(4) Sea(3) |
| Position | 1st Backup | Team | Games | Opponents |
| C | Pedro Pages | StL | 9 | @Cin(5) NYN(4) |
| 1B | Jake Burger | Tex | 7 | Oak(4) Sea(3) |
| 2B | Luis Garcia | Was | 7 | NYN(1) @Phi(3) @Cin(3) |
| SS | Jeremy Pena | Hou | 6 | Det(3) @ChA(3) |
| 3B | Connor Norby | Mia | 6 | @LAD(3) Oak(3) |
| OF | Christopher Morel | TB | 6 | KC(3) @NYA(3) |
| DH (C) | Ryan Jeffers | Min | 7 | @Cle(4) @Bos(3) |
| Position | 2nd Backup | Team | Games | Opponents |
| OF | Heston Kjerstad | Bal | 6 | NYA(3) KC(3) |
| Position | 3rd Backup | Team | Games | Opponents |
| OF | Daulton Varsho | Tor | 6 | Bos(3) Cle(3) |
| Pitching Staff Alignment |
| 8 Starts, 1 Reliever |
| Position | Pitching Order | Team | Games | Opponents | Next Scheduled Start |
| 1st SP | Shota Imanaga | ChN | 6 | @Pit(3) @Mil(3) | This Sunday at Mil (Freddy Peralta) |
| 2nd SP | Hunter Brown | Hou | 6 | Det(3) @ChA(3) | Last Pitched Saturday May 3rd |
| 3rd SP | Nick Pivetta | SD | 5 | SF(2) @Pit(3) | Last Pitched Tuesday April 29th |
| 4th SP | Nathan Eovaldi | Tex | 7 | Oak(4) Sea(3) | Last Pitched Wednesday April 30th |
| 5th SP | Drew Rasmussen | TB | 6 | KC(3) @NYA(3) | Last Pitched Wednesday April 30th |
| 6th SP | Merrill Kelly | Ari | 6 | @NYN(3) @Phi(3) | Last Pitched Friday May 2nd |
| 7th SP | Shane Smith | ChA | 6 | Mil(3) Hou(3) | Last Pitched Wednesday April 30th |
| 8th SP | Justin Verlander | SF | 6 | @SD(2) Col(4) | Last Pitched Thursday May 1st |
| 9th SP | Emerson Hancock | Sea | 5 | LAA(2) @Tex(3) | Last Pitched Wednesday April 30th |
| 10th SP | Zach Eflin | Bal | 6 | NYA(3) KC(3) | Last Pitched Monday April 7th |
| 11th SP | Logan Gilbert | Sea | 5 | LAA(2) @Tex(3) | Last Pitched Friday April 25th |
| 12th SP | Nestor Cortes Jr. | Mil | 6 | @ChA(3) ChN(3) | Last Pitched Thursday April 3rd |
| 1st RP | Devin Williams | NYA | 6 | @Bal(3) TB(3) | Last Pitched Friday May 2nd |
| Position | Injured List | Team | Games | Opponents |
| SP | Lance McCullers | Hou | 6 | Det(3) @ChA(3) |
| SP | Blake Snell | LAD | 6 | Mia(3) @Atl(3) |
| OF | Colton Cowser | Bal | 6 | NYA(3) KC(3) |