| Position | Starters | Team | Games | Opponents |
| C | Shea Langeliers | Oak | 7 | @Tex(4) @Mia(3) |
| 1B | Josh Naylor | Ari | 6 | @NYN(3) @Phi(3) |
| 2B (OF) | Tommy Edman | LAD | 6 | Mia(3) @Atl(3) |
| SS (3B) | Josh Smith | Tex | 7 | Oak(4) Sea(3) |
| 3B | Matt Chapman | SF | 6 | @SD(2) Col(4) |
| OF | Kyle Schwarber | Phi | 6 | Was(3) Ari(3) |
| OF | Aaron Judge | NYA | 6 | @Bal(3) TB(3) |
| OF | Pavin Smith | Ari | 6 | @NYN(3) @Phi(3) |
| DH | Marcell Ozuna | Atl | 6 | @Col(3) LAD(3) |
| Position | 1st Backup | Team | Games | Opponents |
| C | Bo Naylor | Cle | 7 | Min(4) @Tor(3) |
| 1B | Ben Rice | NYA | 6 | @Bal(3) TB(3) |
| 2B (OF) | Gavin Lux | Cin | 8 | StL(5) Was(3) |
| SS | Brayan Rocchio | Cle | 7 | Min(4) @Tor(3) |
| 3B (SS) | Oswaldo Cabrera | NYA | 6 | @Bal(3) TB(3) |
| OF | Cody Bellinger | NYA | 6 | @Bal(3) TB(3) |
| DH (OF) | Ceddanne Rafaela | Bos | 6 | @Tor(3) Min(3) |
| Position | 2nd Backup | Team | Games | Opponents |
| 2B | Jeff McNeil | NYN | 8 | @Was(1) Ari(3) @StL(4) |
| OF | Jorge Soler | LAA | 6 | @Sea(2) Det(4) |
| DH (2B) | Nolan Gorman | StL | 9 | @Cin(5) NYN(4) |
| Pitching Staff Alignment |
| 7 Starts, 2 Relievers |
| Position | Pitching Order | Team | Games | Opponents | Next Scheduled Start |
| 1st SP | Jack Flaherty | Det | 7 | @Hou(3) @LAA(4) | Last Pitched Saturday May 3rd |
| 2nd SP | Reese Olson | Det | 7 | @Hou(3) @LAA(4) | This Sunday at LAA (Jack Kochanowicz) |
| 3rd SP | Chris Bassitt | Tor | 6 | Bos(3) Cle(3) | Last Pitched Friday May 2nd |
| 4th SP | Merrill Kelly | Ari | 6 | @NYN(3) @Phi(3) | Last Pitched Friday May 2nd |
| 5th SP | Chris Sale | Atl | 6 | @Col(3) LAD(3) | Last Pitched Wednesday April 30th |
| 6th SP | Erick Fedde | StL | 9 | @Cin(5) NYN(4) | This Sunday vs NYN (Blade Tidwell) |
| 7th SP | Cristopher Sanchez | Phi | 6 | Was(3) Ari(3) | Last Pitched Wednesday April 30th |
| 8th SP | Luis Ortiz | Cle | 7 | Min(4) @Tor(3) | Last Pitched Wednesday April 30th |
| 1st RP | Emmanuel Clase | Cle | 7 | Min(4) @Tor(3) | Last Pitched Saturday May 3rd |
| 2nd RP | Will Vest | Det | 7 | @Hou(3) @LAA(4) | Last Pitched Tuesday April 29th |
| 3rd RP | Felix Bautista | Bal | 6 | NYA(3) KC(3) | Last Pitched Friday May 2nd |
| 4th RP | Dennis Santana | Pit | 6 | ChN(3) SD(3) | Last Pitched Friday April 25th |
| Position | Injured List | Team | Games | Opponents |
| SS | Corey Seager | Tex | 7 | Oak(4) Sea(3) |
| SP | Shane Bieber | Cle | 7 | Min(4) @Tor(3) |