| Position | Starters | Team | Games | Opponents |
| C | Francisco Álvarez | NYN | 8 | @Was(1) Ari(3) @StL(4) |
| 1B | Josh Naylor | Ari | 6 | @NYN(3) @Phi(3) |
| 2B | Jose Altuve | Hou | 6 | Det(3) @ChA(3) |
| SS | Corey Seager | Tex | 7 | Oak(4) Sea(3) |
| 3B | Junior Caminero | TB | 6 | KC(3) @NYA(3) |
| OF | Seiya Suzuki | ChN | 6 | @Pit(3) @Mil(3) |
| OF | Mike Trout | LAA | 6 | @Sea(2) Det(4) |
| OF | Corbin Carroll | Ari | 6 | @NYN(3) @Phi(3) |
| DH (2B) | Brice Turang | Mil | 6 | @ChA(3) ChN(3) |
| Position | 1st Backup | Team | Games | Opponents |
| C | Drake Baldwin | Atl | 6 | @Col(3) LAD(3) |
| 1B | Paul Goldschmidt | NYA | 6 | @Bal(3) TB(3) |
| SS | Trevor Story | Bos | 6 | @Tor(3) Min(3) |
| 3B | Connor Norby | Mia | 6 | @LAD(3) Oak(3) |
| OF | Andy Pages | LAD | 6 | Mia(3) @Atl(3) |
| DH (OF) | Mickey Moniak | Col | 7 | Atl(3) @SF(4) |
| Position | 2nd Backup | Team | Games | Opponents |
| 3B (OF) | Zach Dezenzo | Hou | 6 | Det(3) @ChA(3) |
| OF | Jo Adell | LAA | 6 | @Sea(2) Det(4) |
| Position | 3rd Backup | Team | Games | Opponents |
| OF | Jhonkensy Noel | Cle | 7 | Min(4) @Tor(3) |
| DH (OF) | Joc Pederson | Tex | 7 | Oak(4) Sea(3) |
| Position | Bench | Team | Games | Opponents |
| 1B | Jac Caglianone | KC | 6 | @TB(3) @Bal(3) |
| 3B | Matt Shaw | ChN | 6 | @Pit(3) @Mil(3) |
| Pitching Staff Alignment |
| 7 Starts, 2 Relievers |
| Position | Pitching Order | Team | Games | Opponents | Next Scheduled Start |
| 1st SP | Shane Baz | TB | 6 | KC(3) @NYA(3) | Last Pitched Thursday May 1st |
| 2nd SP | Spencer Schwellenbach | Atl | 6 | @Col(3) LAD(3) | Last Pitched Saturday May 3rd |
| 3rd SP | Robbie Ray | SF | 6 | @SD(2) Col(4) | Last Pitched Friday May 2nd |
| 4th SP | Jacob deGrom | Tex | 7 | Oak(4) Sea(3) | This Sunday vs Sea (Logan Evans) |
| 5th SP | Matthew Liberatore | StL | 9 | @Cin(5) NYN(4) | Last Pitched Thursday May 1st |
| 6th SP | Zac Gallen | Ari | 6 | @NYN(3) @Phi(3) | Last Pitched Thursday May 1st |
| 7th SP | David Peterson | NYN | 8 | @Was(1) Ari(3) @StL(4) | Last Pitched Tuesday April 29th |
| 8th SP | Mitch Keller | Pit | 6 | ChN(3) SD(3) | Last Pitched Friday May 2nd |
| 1st RP | Robert Suarez | SD | 5 | SF(2) @Pit(3) | Last Pitched Saturday May 3rd |
| 2nd RP | Ryan Helsley | StL | 9 | @Cin(5) NYN(4) | Last Pitched Friday May 2nd |
| Position | Injured List | Team | Games | Opponents |
| OF | Garrett Mitchell | Mil | 6 | @ChA(3) ChN(3) |
| C | Ivan Herrera | StL | 9 | @Cin(5) NYN(4) |
| OF | Daulton Varsho | Tor | 6 | Bos(3) Cle(3) |