| Position | Starters | Team | Games | Opponents |
| C | Logan O'Hoppe | LAA | 6 | @Sea(2) Det(4) |
| 1B | Matt Olson | Atl | 6 | @Col(3) LAD(3) |
| 2B | Gleyber Torres | Det | 7 | @Hou(3) @LAA(4) |
| SS | Francisco Lindor | NYN | 7 | @Was(1) Ari(3) @StL(3) |
| 3B | Eugenio Suarez | Ari | 6 | @NYN(3) @Phi(3) |
| OF | Ian Happ | ChN | 6 | @Pit(3) @Mil(3) |
| OF | Brandon Nimmo | NYN | 7 | @Was(1) Ari(3) @StL(3) |
| OF | Bryan Reynolds | Pit | 6 | ChN(3) SD(3) |
| DH (SS) | Dansby Swanson | ChN | 6 | @Pit(3) @Mil(3) |
| Position | 1st Backup | Team | Games | Opponents |
| C | Joey Bart | Pit | 6 | ChN(3) SD(3) |
| 1B | Joshua Bell | Was | 7 | NYN(1) @Phi(3) @Cin(3) |
| 3B | Dylan Moore | Sea | 5 | LAA(2) @Tex(3) |
| OF | Nick Castellanos | Phi | 6 | Was(3) Ari(3) |
| DH (OF) | Victor Scott | StL | 8 | @Cin(5) NYN(3) |
| Position | 2nd Backup | Team | Games | Opponents |
| OF | George Springer | Tor | 6 | Bos(3) Cle(3) |
| Position | Bench | Team | Games | Opponents |
| OF | Jake Fraley | Cin | 8 | StL(5) Was(3) |
| Pitching Staff Alignment |
| 7 Starts, 2 Relievers |
| Position | Pitching Order | Team | Games | Opponents | Next Scheduled Start |
| 1st SP | Nick Pivetta | SD | 5 | SF(2) @Pit(3) | This Sunday at Pit (Andrew Heaney) |
| 2nd SP | Dylan Cease | SD | 5 | SF(2) @Pit(3) | Last Pitched Friday May 2nd |
| 3rd SP | Framber Valdez | Hou | 6 | Det(3) @ChA(3) | Last Pitched Friday May 2nd |
| 4th SP | Logan Webb | SF | 6 | @SD(2) Col(4) | This Sunday vs Col (Germán Márquez) |
| 5th SP | Erick Fedde | StL | 8 | @Cin(5) NYN(3) | This Saturday vs NYN (Tylor Megill) |
| 6th SP | Chris Bassitt | Tor | 6 | Bos(3) Cle(3) | Last Pitched Friday May 2nd |
| 7th SP | Andrew Heaney | Pit | 6 | ChN(3) SD(3) | This Sunday vs SD (Nick Pivetta) |
| 8th SP | Jose Berrios | Tor | 6 | Bos(3) Cle(3) | Last Pitched Thursday May 1st |
| 9th SP | Jameson Taillon | ChN | 6 | @Pit(3) @Mil(3) | This Saturday at Mil (Jose Quintana) |
| 10th SP | AJ Smith-Shawver | Atl | 6 | @Col(3) LAD(3) | Last Pitched Tuesday April 29th |
| 1st RP | Josh Hader | Hou | 6 | Det(3) @ChA(3) | Last Pitched Tuesday April 29th |
| 2nd RP | Jeff Hoffman | Tor | 6 | Bos(3) Cle(3) | Last Pitched Friday May 2nd |
| 3rd RP | Kenley Jansen | LAA | 6 | @Sea(2) Det(4) | Last Pitched Friday May 2nd |
| 4th RP | Emilio Pagan | Cin | 8 | StL(5) Was(3) | Last Pitched Friday May 2nd |
| 5th RP | Will Vest | Det | 7 | @Hou(3) @LAA(4) | Last Pitched Tuesday April 29th |
| Position | Injured List | Team | Games | Opponents |
| SP | Aaron Civale | Mil | 6 | @ChA(3) ChN(3) |
| 2B | Willi Castro | Min | 7 | @Cle(4) @Bos(3) |