| Position | Starters | Team | Games | Opponents |
| C | Gabriel Moreno | Ari | 6 | @NYN(3) @Phi(3) |
| 1B | Josh Naylor | Ari | 6 | @NYN(3) @Phi(3) |
| 2B | Andrés Gimenez | Tor | 6 | Bos(3) Cle(3) |
| SS | Anthony Volpe | NYA | 6 | @Bal(3) TB(3) |
| 3B | Isaac Paredes | Hou | 6 | Det(3) @ChA(3) |
| OF | Julio Rodriguez | Sea | 5 | LAA(2) @Tex(3) |
| OF | Teoscar Hernández | LAD | 6 | Mia(3) @Atl(3) |
| OF | Juan Soto | NYN | 7 | @Was(1) Ari(3) @StL(3) |
| DH (2B) | Matt McLain | Cin | 8 | StL(5) Was(3) |
| Position | 1st Backup | Team | Games | Opponents |
| C | Joey Bart | Pit | 6 | ChN(3) SD(3) |
| 2B | Luis Rengifo | LAA | 6 | @Sea(2) Det(4) |
| SS | Diego Castillo | Min | 7 | @Cle(4) @Bos(3) |
| 3B | Dylan Moore | Sea | 5 | LAA(2) @Tex(3) |
| OF | Spencer Steer | Cin | 8 | StL(5) Was(3) |
| Position | 2nd Backup | Team | Games | Opponents |
| 2B | Nico Hoerner | ChN | 6 | @Pit(3) @Mil(3) |
| OF | Garrett Mitchell | Mil | 6 | @ChA(3) ChN(3) |
| DH (OF) | Roman Anthony | Bos | 6 | @Tor(3) Min(3) |
| Position | Bench | Team | Games | Opponents |
| SS | Jon Berti | ChN | 6 | @Pit(3) @Mil(3) |
| Pitching Staff Alignment |
| 10 Starts, 0 Relievers |
| Position | Pitching Order | Team | Games | Opponents | Next Scheduled Start |
| 1st SP | Max Fried | NYA | 6 | @Bal(3) TB(3) | Last Pitched Friday May 2nd |
| 2nd SP | George Kirby | Sea | 5 | LAA(2) @Tex(3) | Has Not Played Yet |
| 3rd SP | Roki Sasaki | LAD | 6 | Mia(3) @Atl(3) | This Saturday at Atl (Spencer Schwellenbach) |
| 4th SP | Bryan Woo | Sea | 5 | LAA(2) @Tex(3) | Last Pitched Friday May 2nd |
| 5th SP | Grayson Rodriguez | Bal | 6 | NYA(3) KC(3) | Has Not Played Yet |
| 6th SP | Gavin Williams | Cle | 7 | Min(4) @Tor(3) | This Saturday at Tor (Kevin Gausman) |
| 7th SP | Brayan Bello | Bos | 6 | @Tor(3) Min(3) | Last Pitched Friday May 2nd |
| 1st RP | Carlos Estevez | KC | 6 | @TB(3) @Bal(3) | Last Pitched Wednesday April 30th |
| 2nd RP | Liam Hendriks | Bos | 6 | @Tor(3) Min(3) | Last Pitched Friday May 2nd |
| 3rd RP | Kirby Yates | LAD | 6 | Mia(3) @Atl(3) | Last Pitched Friday May 2nd |
| 4th RP | Bryan Abreu | Hou | 6 | Det(3) @ChA(3) | Last Pitched Tuesday April 29th |
| 5th RP | Camilo Doval | SF | 6 | @SD(2) Col(4) | Last Pitched Thursday May 1st |
| Position | Injured List | Team | Games | Opponents |
| C | David Fry | Cle | 7 | Min(4) @Tor(3) |
| DH | Ronald Acuna Jr. | Atl | 6 | @Col(3) LAD(3) |