| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Travis d'Arnaud | C (DH) | Atl | 31 | |
| Daulton Varsho | C (OF,DH) | Ari | 24 | |
| Jose Abreu | 1B (DH) | ChA | 33 | |
| Ryan O'Hearn | 1B (DH) | KC | 27 | |
| Mike Moustakas | 2B (1B,DH) | Cin | 32 | |
| Jurickson Profar | 2B (OF) | SD | 27 | |
| Jazz Chisholm | SS (2B) | Mia | 22 | |
| Niko Goodrum | SS (2B) | Det | 28 | |
| Marcus Semien | SS | Oak | 30 | |
| Alex Bregman | 3B | Hou | 26 | |
| Yandy Diaz | 3B (DH) | TB | 29 | September 01, 2020:10 Day IL-Strained right hamstring |
| Andrew Benintendi | OF | Bos | 26 | August 12, 2020:10 Day IL-Strained right ribcage |
| Ian Happ | OF | ChN | 26 | |
| Kike Hernandez | OF (2B) | LAD | 29 | |
| Kyle Lewis | OF | Sea | 25 | |
| Starling Marte | OF | Mia | 32 | |
| Wil Myers | OF | SD | 29 | |
| Luis Robert | OF | ChA | 23 | |
| Kyle Schwarber | OF (DH) | ChN | 27 | |
| Nick Senzel | OF | Cin | 25 | |
| J.D. Martinez | DH (OF) | Bos | 33 | |
| Griffin Canning | SP | LAA | 24 | |
| Aaron Civale | SP | Cle | 25 | |
| J.A. Happ | SP | NYA | 38 | |
| Tanner Houck | SP | Bos | 24 | |
| Josh James | SP (RP) | Hou | 27 | September 25, 2020:10 Day IL-Undisclosed Injury |
| Kwang-Hyun Kim | SP | StL | 32 | |
| Corey Kluber | SP | Tex | 34 | July 28, 2020:15 Day IL-Abdomen |
| Sean Manaea | SP | Oak | 28 | |
| Justin Verlander | SP | Hou | 37 | July 25, 2020:15 Day IL-Abdomen |
| Michael Wacha | SP | NYN | 29 | |
| Hector Neris | RP | Phi | 31 | |
| Will Smith | RP | Atl | 31 | |
| Blake Treinen | RP | LAD | 32 |