| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Yasmani Grandal | C (1B,DH) | ChA | 32 | |
| Adley Rutschman | C | Bal | 22 | |
| Paul Goldschmidt | 1B (DH) | StL | 33 | |
| Rhys Hoskins | 1B | Phi | 27 | September 13, 2020:10 Day IL-UCL injury, left forearm |
| Nathaniel Lowe | 1B (DH) | TB | 25 | |
| Ryan O'Hearn | 1B (DH) | KC | 27 | |
| Nico Hoerner | 2B (3B,SS) | ChN | 23 | |
| Ryan McMahon | 2B (1B,3B) | Col | 25 | |
| J.P. Crawford | SS | Sea | 25 | |
| Jorge Polanco | SS | Min | 27 | |
| Bobby Dalbec | 3B (1B) | Bos | 25 | |
| Yandy Diaz | 3B (DH) | TB | 29 | September 01, 2020:10 Day IL-Strained right hamstring |
| Josh Donaldson | 3B | Min | 34 | |
| Nick Solak | 3B (2B,OF,DH) | Tex | 25 | |
| Andrew Benintendi | OF | Bos | 26 | August 12, 2020:10 Day IL-Strained right ribcage |
| Nick Castellanos | OF | Cin | 28 | |
| David Dahl | OF | Col | 26 | September 23, 2020:60 Day IL-Strained right shoulder |
| Tommy Edman | OF (2B,3B,SS) | StL | 25 | |
| Austin Hays | OF | Bal | 25 | |
| Jarred Kelenic | OF | Sea | 21 | |
| Alex Kirilloff | OF | Min | 23 | |
| Kyle Lewis | OF | Sea | 25 | |
| Khris Davis | DH | Oak | 32 | |
| Dylan Cease | SP | ChA | 24 | |
| Andrew Heaney | SP | LAA | 29 | |
| Tanner Houck | SP | Bos | 24 | |
| Steven Matz | SP (RP) | NYN | 28 | |
| Dustin May | SP (RP) | LAD | 23 | |
| Jose Quintana | SP (RP) | ChN | 31 | |
| Julio Urías | SP | LAD | 24 | |
| Michael Wacha | SP | NYN | 29 | |
| Zach Wheeler | SP | Phi | 30 | |
| Ryan Yarbrough | SP (RP) | TB | 28 | |
| Giovanny Gallegos | RP | StL | 29 |