| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Ivan Herrera | C | StL | 24 | April 07, 2025:15 Day IL-Knee |
| Ryan Jeffers | C | Min | 27 | |
| Pedro Pages | C | StL | 26 | |
| Jake Burger | 1B | Tex | 29 | |
| Ty France | 1B | Min | 30 | |
| Josh Naylor | 1B | Ari | 27 | |
| Luis Garcia | 2B | Was | 24 | |
| Nolan Gorman | 2B | StL | 24 | |
| CJ Abrams | SS | Was | 24 | |
| Jeremy Pena | SS | Hou | 27 | |
| Josh Jung | 3B | Tex | 27 | |
| Connor Norby | 3B | Mia | 24 | |
| Colton Cowser | OF | Bal | 25 | March 31, 2025:60 Day IL-Left thumb fracture |
| TJ Friedl | OF | Cin | 29 | |
| Adolis Garcia | OF | Tex | 32 | |
| Christopher Morel | OF | TB | 25 | |
| Bryan Reynolds | OF | Pit | 30 | |
| Julio Rodriguez | OF | Sea | 24 | |
| Daulton Varsho | OF | Tor | 28 | |
| Hunter Brown | SP | Hou | 26 | |
| Zach Eflin | SP | Bal | 31 | April 09, 2025:15 Day IL |
| Nathan Eovaldi | SP | Tex | 35 | |
| Logan Gilbert | SP | Sea | 27 | April 26, 2025:15 Day IL |
| Emerson Hancock | SP | Sea | 25 | |
| Shota Imanaga | SP | ChN | 31 | |
| Merrill Kelly | SP | Ari | 36 | |
| Lance McCullers | SP | Hou | 31 | March 27, 2025:15 Day IL |
| Nick Pivetta | SP | SD | 32 | |
| Drew Rasmussen | SP | TB | 29 | |
| Shane Smith | SP | ChA | N/A | |
| Blake Snell | SP | LAD | 32 | April 06, 2025:15 Day IL-Ab strain |
| Justin Verlander | SP | SF | 42 | |
| Aroldis Chapman | RP | Bos | 37 | |
| Devin Williams | RP | NYA | 30 |