| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Ivan Herrera | C | StL | 25 | June 20, 2025:10 Day IL |
| Pedro Pages | C | StL | 26 | |
| J.T. Realmuto | C | Phi | 34 | |
| Paul Goldschmidt | 1B | NYA | 37 | |
| Josh Naylor | 1B | Ari | 28 | |
| Thairo Estrada | 2B | Col | 29 | |
| Nick Gonzales | 2B | Pit | 26 | |
| Otto Lopez | 2B (SS) | Mia | 26 | |
| Brandon Lowe | 2B | TB | 31 | |
| Mookie Betts | SS | LAD | 32 | |
| Trevor Story | SS | Bos | 32 | |
| JJ Wetherholt | SS | StL | 22 | |
| Alec Bohm | 3B (1B) | Phi | 28 | |
| Matt Chapman | 3B | SF | 32 | |
| Eugenio Suarez | 3B | Ari | 33 | |
| Riley Greene | OF | Det | 24 | |
| Josh Lowe | OF | TB | 27 | |
| Lars Nootbaar | OF | StL | 27 | |
| Wenceel Perez | OF | Det | N/A | |
| Heliot Ramos | OF | SF | 25 | |
| Mike Trout | OF | LAA | 33 | |
| Spencer Arrighetti | SP | Hou | N/A | April 08, 2025:60 Day IL |
| Tanner Bibee | SP | Cle | 26 | |
| Joe Boyle | SP | TB | 25 | |
| Hunter Brown | SP | Hou | 26 | |
| Gerrit Cole | SP | NYA | 34 | March 22, 2025:60 Day IL |
| MacKenzie Gore | SP | Was | 26 | |
| Adrian Houser | SP | ChA | 32 | |
| Shane McClanahan | SP | TB | 28 | March 26, 2025:60 Day IL-Ab strain |
| Jacob Misiorowski | SP | Mil | N/A | |
| Ranger Suarez | SP | Phi | 29 | |
| Felix Bautista | RP | Bal | 30 | |
| Edwin Diaz | RP | NYN | 31 | |
| Emilio Pagan | RP | Cin | 34 |