| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Ivan Herrera | C | StL | 25 | |
| J.T. Realmuto | C | Phi | 34 | |
| Blake Burke | 1B | Mil | 22 | |
| Josh Naylor | 1B | Sea | 28 | |
| Andrew Vaughn | 1B | Mil | 27 | |
| Nick Gonzales | 2B (SS) | Pit | 26 | |
| Otto Lopez | 2B (SS) | Mia | 27 | |
| Brandon Lowe | 2B | TB | 31 | |
| Mookie Betts | SS | LAD | 33 | |
| Trevor Story | SS | Bos | 32 | |
| JJ Wetherholt | SS | StL | 23 | |
| Brett Baty | 3B (2B) | NYN | 25 | September 27, 2025:10 Day IL |
| Matt Chapman | 3B | SF | 32 | |
| Sal Stewart | 3B (1B) | Cin | 21 | |
| Eugenio Suarez | 3B | Sea | 34 | |
| Justin Crawford | OF | Phi | 21 | |
| Chase DeLauter | OF | Cle | 24 | |
| Riley Greene | OF | Det | 25 | |
| Josh Lowe | OF | TB | 27 | |
| Lars Nootbaar | OF | StL | 28 | |
| Heliot Ramos | OF | SF | 26 | |
| Mike Trout | OF | LAA | 34 | |
| Joe Boyle | SP (RP) | TB | 26 | |
| Hunter Brown | SP | Hou | 27 | |
| Gerrit Cole | SP | NYA | 35 | March 22, 2025:60 Day IL |
| Yu Darvish | SP | SD | 39 | |
| MacKenzie Gore | SP | Was | 26 | September 23, 2025:15 Day IL |
| Adrian Houser | SP | TB | 32 | |
| Shane McClanahan | SP | TB | 28 | March 26, 2025:60 Day IL-Ab strain |
| Jacob Misiorowski | SP | Mil | N/A | |
| Charlie Morton | SP (RP) | Atl | 41 | |
| Ranger Suarez | SP | Phi | 30 | |
| Edwin Diaz | RP | NYN | 31 |