| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Francisco Álvarez | C | NYN | 23 | |
| Drake Baldwin | C | Atl | 24 | |
| Ivan Herrera | C | StL | 24 | April 07, 2025:15 Day IL-Knee |
| Jac Caglianone | 1B | KC | 22 | |
| Paul Goldschmidt | 1B | NYA | 37 | |
| Josh Naylor | 1B | Ari | 27 | |
| Jose Altuve | 2B (OF) | Hou | 34 | |
| Brice Turang | 2B | Mil | 25 | |
| Corey Seager | SS | Tex | 31 | April 23, 2025:10 Day IL |
| Trevor Story | SS | Bos | 32 | |
| Junior Caminero | 3B | TB | 21 | |
| Zach Dezenzo | 3B (OF) | Hou | N/A | |
| Connor Norby | 3B | Mia | 24 | |
| Matt Shaw | 3B | ChN | 23 | |
| Jo Adell | OF | LAA | 26 | |
| Corbin Carroll | OF | Ari | 24 | |
| Garrett Mitchell | OF | Mil | 26 | April 26, 2025:10 Day IL |
| Mickey Moniak | OF | Col | 26 | |
| Jhonkensy Noel | OF | Cle | 23 | |
| Andy Pages | OF | LAD | 24 | |
| Joc Pederson | OF | Tex | 33 | |
| Seiya Suzuki | OF | ChN | 30 | |
| Mike Trout | OF | LAA | 33 | May 02, 2025:10 Day IL |
| Daulton Varsho | OF | Tor | 28 | |
| Shane Baz | SP | TB | 25 | |
| Jacob deGrom | SP | Tex | 36 | |
| Zac Gallen | SP | Ari | 29 | |
| Mitch Keller | SP | Pit | 29 | |
| Matthew Liberatore | SP | StL | 25 | |
| David Peterson | SP | NYN | 29 | |
| Robbie Ray | SP | SF | 33 | |
| Spencer Schwellenbach | SP | Atl | 24 | |
| Ryan Helsley | RP | StL | 30 | |
| Robert Suarez | RP | SD | 34 |