| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Moises Ballesteros | C | ChN | 21 | |
| Ivan Herrera | C | StL | 24 | April 07, 2025:15 Day IL-Knee |
| Agustin Ramirez | C | Mia | 23 | |
| Jac Caglianone | 1B | KC | 22 | |
| Nick Kurtz | 1B | Oak | 22 | |
| Josh Naylor | 1B | Ari | 27 | |
| Michael Toglia | 1B | Col | 26 | |
| Travis Bazzana | 2B | Cle | 22 | |
| Matt McLain | 2B | Cin | 25 | |
| Jose Caballero | SS (3B,OF) | TB | 28 | |
| Anthony Volpe | SS | NYA | 24 | |
| Sebastian Walcott | SS | Tex | 19 | |
| Brady House | 3B | Was | 21 | |
| Josh Jung | 3B | Tex | 27 | |
| Royce Lewis | 3B | Min | 25 | March 27, 2025:15 Day IL-Ab strain |
| Noelvi Marte | 3B | Cin | 23 | |
| Max Muncy | 3B | LAD | 34 | |
| Cam Smith | 3B (OF) | Hou | 22 | |
| Evan Carter | OF | Tex | 22 | |
| Oneil Cruz | OF | Pit | 26 | |
| Lazaro Montes | OF | Sea | 20 | |
| Christopher Morel | OF | TB | 25 | |
| Jorge Soler | OF | LAA | 32 | |
| Ronel Blanco | SP | Hou | 31 | |
| Matt Boyd | SP | ChN | 34 | |
| Bubba Chandler | SP | Pit | N/A | |
| Zach Eflin | SP | Bal | 31 | April 09, 2025:15 Day IL |
| Jacob Misiorowski | SP | Mil | N/A | |
| Ryan Pepiot | SP | TB | 27 | |
| Roki Sasaki | SP | LAD | 23 | |
| Clarke Schmidt | SP | NYA | 29 | |
| Ryan Helsley | RP | StL | 30 | |
| Raisel Iglesias | RP | Atl | 35 | |
| Will Vest | RP | Det | 29 |