| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Yainer Diaz | C | Hou | 26 | |
| Shea Langeliers | C | Oak | 27 | |
| Josh Naylor | 1B | Ari | 27 | |
| Ryan O'Hearn | 1B (OF) | Bal | 31 | |
| Eric Wagaman | 1B (OF) | Mia | N/A | |
| Nick Gonzales | 2B | Pit | 25 | March 28, 2025:10 Day IL |
| Jonathan India | 2B (3B,OF) | KC | 28 | |
| Otto Lopez | 2B | Mia | 26 | |
| Bryson Stott | 2B | Phi | 27 | |
| Gabriel Arias | SS (2B,3B) | Cle | 25 | |
| Zach Neto | SS | LAA | 24 | |
| Ezequiel Tovar | SS | Col | 23 | April 19, 2025:10 Day IL |
| Maikel Garcia | 3B (2B,OF) | KC | 25 | |
| Ryan McMahon | 3B | Col | 30 | |
| Hunter Goodman | OF (C) | Col | 25 | |
| Ian Happ | OF | ChN | 30 | |
| Josh Lowe | OF | TB | 27 | March 29, 2025:10 Day IL |
| Christopher Morel | OF | TB | 25 | |
| Heliot Ramos | OF | SF | 25 | |
| Juan Soto | OF | NYN | 26 | |
| Christian Yelich | OF | Mil | 33 | |
| Corbin Burnes | SP | Ari | 30 | |
| Merrill Kelly | SP | Ari | 36 | |
| Michael King | SP | SD | 29 | |
| Pablo Lopez | SP | Min | 29 | |
| Nick Pivetta | SP | SD | 32 | |
| JP Sears | SP | Oak | 29 | |
| Tarik Skubal | SP | Det | 28 | |
| José Soriano | SP | LAA | 26 | |
| Hayden Wesneski | SP | Hou | 27 | |
| Brandon Woodruff | SP | Mil | 32 | March 27, 2025:15 Day IL |
| Emmanuel Clase | RP | Cle | 27 | |
| Jhoan Duran | RP | Min | 27 | |
| Jeff Hoffman | RP | Tor | 32 |