| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Logan O'Hoppe | C | LAA | 25 | |
| Keibert Ruiz | C | Was | 26 | |
| Pete Alonso | 1B | NYN | 30 | |
| Luis Arraez | 1B | SD | 28 | |
| Joshua Bell | 1B | Was | 32 | |
| Andrés Gimenez | 2B | Tor | 26 | |
| Nico Hoerner | 2B | ChN | 27 | |
| Ketel Marte | 2B | Ari | 31 | |
| Javier Baez | SS (3B,OF) | Det | 32 | |
| Jeremy Pena | SS | Hou | 27 | |
| Rafael Devers | 3B | Bos | 28 | |
| Dylan Moore | 3B (2B,OF) | Sea | 32 | April 29, 2025:10 Day IL |
| Jackson Chourio | OF | Mil | 21 | |
| Michael Harris II | OF | Atl | 24 | |
| Wyatt Langford | OF | Tex | 23 | |
| Parker Meadows | OF | Det | 25 | March 24, 2025:60 Day IL |
| Luis Robert Jr. | OF | ChA | 27 | |
| Victor Scott | OF | StL | 24 | |
| Alex Verdugo | OF | Atl | 28 | |
| Taj Bradley | SP | TB | 24 | |
| Griffin Canning | SP | NYN | 28 | |
| Gerrit Cole | SP | NYA | 34 | March 22, 2025:60 Day IL |
| Nestor Cortes Jr. | SP | Mil | 30 | April 06, 2025:60 Day IL-Left elbow flexor strain |
| Zach Eflin | SP | Bal | 31 | April 09, 2025:15 Day IL |
| Sonny Gray | SP | StL | 35 | |
| Bailey Ober | SP | Min | 29 | |
| Brandon Pfaadt | SP | Ari | 26 | |
| Joe Ryan | SP | Min | 28 | |
| Chris Sale | SP | Atl | 36 | |
| Clarke Schmidt | SP | NYA | 29 | |
| Spencer Strider | SP | Atl | 26 | April 21, 2025:15 Day IL |
| Yoshinobu Yamamoto | SP | LAD | 26 | |
| Raisel Iglesias | RP | Atl | 35 | |
| Kenley Jansen | RP | LAA | 37 |