| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Dillon Dingler | C | Det | N/A | |
| Ivan Herrera | C | StL | 24 | April 07, 2025:15 Day IL-Knee |
| Salvador Perez | C (C,1B) | KC | 34 | |
| Agustin Ramirez | C | Mia | 23 | |
| Yandy Diaz | 1B | TB | 33 | |
| Josh Naylor | 1B | Ari | 27 | |
| Luke Keaschall | 2B | Min | 22 | April 26, 2025:10 Day IL |
| Brooks Lee | 2B (3B) | Min | 24 | |
| Matt McLain | 2B | Cin | 25 | |
| Gleyber Torres | 2B | Det | 28 | |
| Carlos Correa | SS | Min | 30 | |
| Zach Neto | SS | LAA | 24 | |
| Ezequiel Tovar | SS | Col | 23 | April 19, 2025:10 Day IL |
| Carson Williams | SS | TB | 21 | |
| Junior Caminero | 3B | TB | 21 | |
| Jorge Polanco | 3B | Sea | 31 | |
| Wilyer Abreu | OF | Bos | 25 | |
| JJ Bleday | OF | Oak | 27 | |
| Lawrence Butler | OF | Oak | 24 | |
| Ceddanne Rafaela | OF | Bos | 24 | |
| Heliot Ramos | OF | SF | 25 | |
| Brayan Bello | SP | Bos | 25 | |
| Griffin Canning | SP | NYN | 28 | |
| Nathan Eovaldi | SP | Tex | 35 | |
| Luis Gil | SP | NYA | 26 | March 24, 2025:60 Day IL |
| Tanner Houck | SP | Bos | 28 | |
| Merrill Kelly | SP | Ari | 36 | |
| Lance McCullers | SP | Hou | 31 | March 27, 2025:15 Day IL |
| Bryce Miller | SP | Sea | 26 | |
| Drew Rasmussen | SP | TB | 29 | |
| José Soriano | SP | LAA | 26 | |
| Randy Vasquez | SP | SD | 26 | |
| Carlos Estevez | RP | KC | 32 | |
| Emilio Pagan | RP | Cin | 33 |