| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Joey Bart | C | Pit | 28 | |
| Salvador Perez | C (C,1B) | KC | 34 | |
| Joshua Bell | 1B | Was | 32 | |
| Ben Rice | 1B | NYA | 26 | |
| Brendan Donovan | 2B (SS,OF) | StL | 28 | |
| Brandon Lowe | 2B | TB | 30 | |
| Ketel Marte | 2B | Ari | 31 | |
| Javier Baez | SS (3B,OF) | Det | 32 | |
| Mookie Betts | SS | LAD | 32 | |
| Corey Seager | SS | Tex | 31 | April 23, 2025:10 Day IL |
| Brett Baty | 3B (2B) | NYN | 25 | |
| Josh Jung | 3B | Tex | 27 | |
| Joey Ortiz | 3B (SS) | Mil | 26 | |
| Pete Crow-Armstrong | OF | ChN | 23 | |
| Adolis Garcia | OF | Tex | 32 | |
| Hunter Goodman | OF (C) | Col | 25 | |
| Kameron Misner | OF | TB | N/A | |
| Anthony Santander | OF | Tor | 30 | |
| Gavin Sheets | OF (1B) | SD | 29 | |
| Pavin Smith | OF (1B) | Ari | 29 | |
| Ronel Blanco | SP | Hou | 31 | |
| Matt Boyd | SP | ChN | 34 | |
| Nestor Cortes Jr. | SP | Mil | 30 | April 06, 2025:60 Day IL-Left elbow flexor strain |
| Bowden Francis | SP | Tor | 29 | |
| Cristian Javier | SP | Hou | 28 | March 27, 2025:15 Day IL |
| Jesus Luzardo | SP | Phi | 27 | |
| Brandon Pfaadt | SP | Ari | 26 | |
| Tarik Skubal | SP | Det | 28 | |
| Jameson Taillon | SP | ChN | 33 | |
| David Bednar | RP | Pit | 30 | |
| Jhoan Duran | RP | Min | 27 | |
| Porter Hodge | RP | ChN | 24 | |
| Justin Martinez | RP | Ari | 23 | May 01, 2025:15 Day IL |
| Ryan Walker | RP | SF | N/A |