| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Shea Langeliers | C | Oak | 27 | |
| Keibert Ruiz | C | Was | 26 | |
| Joshua Bell | 1B | Was | 32 | |
| Matt Olson | 1B | Atl | 31 | |
| Jeff McNeil | 2B | NYN | 33 | |
| Gleyber Torres | 2B | Det | 28 | |
| Willy Adames | SS | SF | 29 | |
| Paul DeJong | SS (3B) | Was | 31 | April 16, 2025:10 Day IL-Fractured nose |
| Alex Bregman | 3B | Bos | 31 | |
| Eugenio Suarez | 3B | Ari | 33 | |
| Wilyer Abreu | OF | Bos | 25 | |
| Nick Castellanos | OF | Phi | 33 | |
| Aaron Judge | OF | NYA | 33 | |
| Jurickson Profar | OF | Atl | 32 | |
| Brent Rooker | OF | Oak | 30 | |
| George Springer | OF | Tor | 35 | |
| Hunter Brown | SP | Hou | 26 | |
| Bowden Francis | SP | Tor | 29 | |
| Logan Gilbert | SP | Sea | 27 | April 26, 2025:15 Day IL |
| MacKenzie Gore | SP | Was | 26 | |
| Sonny Gray | SP | StL | 35 | |
| Jake Irvin | SP | Was | 28 | |
| Nick Martinez | SP | Cin | 34 | |
| Ryan Pepiot | SP | TB | 27 | |
| Chris Sale | SP | Atl | 36 | |
| Max Scherzer | SP | Tor | 40 | March 30, 2025:15 Day IL-Thumb |
| Mike Soroka | SP | Was | 27 | April 04, 2025:15 Day IL |
| Trevor Williams | SP | Was | 33 | |
| Brandon Woodruff | SP | Mil | 32 | March 27, 2025:15 Day IL |
| Chris Martin | RP | Tex | 38 |