| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Alejandro Kirk | C | Tor | 26 | |
| Salvador Perez | C (C,1B) | KC | 35 | |
| Nathaniel Lowe | 1B | Bos | 30 | |
| Josh Naylor | 1B | Sea | 28 | |
| Jose Altuve | 2B (OF) | Hou | 35 | |
| Isaac Collins | 2B (OF) | Mil | N/A | |
| Brendan Donovan | 2B (SS,OF) | StL | 28 | |
| Xavier Edwards | SS (2B) | Mia | 26 | |
| Trevor Story | SS | Bos | 32 | |
| Dansby Swanson | SS | ChN | 31 | |
| Nolan Arenado | 3B | StL | 34 | |
| Matt Chapman | 3B | SF | 32 | |
| Ke'Bryan Hayes | 3B | Cin | 28 | |
| Miguel Vargas | 3B (1B) | ChA | 25 | |
| Jarren Duran | OF | Bos | 29 | |
| Adolis Garcia | OF | Tex | 32 | |
| Teoscar Hernández | OF | LAD | 32 | |
| Josh Lowe | OF | TB | 27 | |
| Anthony Santander | OF | Tor | 30 | May 30, 2025:10 Day IL |
| Mike Trout | OF | LAA | 34 | |
| Taylor Ward | OF | LAA | 31 | |
| Marcell Ozuna | DH | Atl | 34 | |
| Nathan Eovaldi | SP | Tex | 35 | August 27, 2025:15 Day IL |
| Luis Gil | SP | NYA | 27 | |
| Lucas Giolito | SP | Bos | 31 | |
| Merrill Kelly | SP | Tex | 36 | |
| Seth Lugo | SP | KC | 35 | September 04, 2025:15 Day IL |
| Ryan Pepiot | SP | TB | 28 | |
| Brady Singer | SP | Cin | 29 | |
| Jeffrey Springs | SP | Oak | 32 | |
| Emmanuel Clase | RP | Cle | 27 | |
| Carlos Estevez | RP | KC | 32 | |
| Dennis Santana | RP | Pit | 29 | |
| Cade Smith | RP | Cle | N/A |