| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Dillon Dingler | C | Det | N/A | |
| Shea Langeliers | C | Oak | 27 | |
| Josh Naylor | 1B | Sea | 28 | |
| Ben Rice | 1B (C) | NYA | 26 | |
| Kristian Campbell | 2B (OF) | Bos | 23 | |
| Marcus Semien | 2B | Tex | 35 | August 23, 2025:10 Day IL |
| Bo Bichette | SS | Tor | 27 | September 09, 2025:10 Day IL |
| Chase Meidroth | 3B (2B,SS) | ChA | N/A | |
| Max Muncy | 3B | LAD | 35 | |
| Josh Smith | 3B (1B,SS,OF) | Tex | 28 | |
| Tommy Edman | OF (2B,3B) | LAD | 30 | |
| TJ Friedl | OF | Cin | 30 | |
| Walker Jenkins | OF | Min | 20 | |
| Andy Pages | OF | LAD | 24 | |
| Luis Robert Jr. | OF | ChA | 28 | August 27, 2025:10 Day IL |
| Kyle Schwarber | OF | Phi | 32 | |
| Kyle Stowers | OF | Mia | 27 | August 17, 2025:10 Day IL |
| Christian Yelich | OF | Mil | 33 | |
| Braxton Ashcraft | SP (RP) | Pit | N/A | |
| Kris Bubic | SP | KC | 28 | July 27, 2025:15 Day IL |
| Noah Cameron | SP | KC | N/A | |
| Nestor Cortes Jr. | SP | SD | 30 | September 05, 2025:15 Day IL |
| Hunter Greene | SP | Cin | 26 | |
| George Kirby | SP | Sea | 27 | |
| Tyler Mahle | SP | Tex | 30 | June 15, 2025:60 Day IL |
| Michael McGreevy | SP | StL | 25 | |
| Luis Morales | SP | Oak | 22 | |
| David Peterson | SP | NYN | 30 | |
| Nick Pivetta | SP | SD | 32 | |
| Jose Quintana | SP | Mil | 36 | |
| Roki Sasaki | SP | LAD | 23 | May 13, 2025:60 Day IL |
| Jeffrey Springs | SP | Oak | 32 | |
| Carlos Estevez | RP | KC | 32 | |
| Will Vest | RP | Det | 30 |