| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Jonah Heim | C | Tex | 29 | |
| Keibert Ruiz | C | Was | 26 | |
| Joshua Bell | 1B | Was | 32 | |
| Ty France | 1B | Min | 30 | |
| Andrés Gimenez | 2B | Tor | 26 | |
| Bryson Stott | 2B | Phi | 27 | |
| Brice Turang | 2B | Mil | 25 | |
| Javier Baez | SS (3B,OF) | Det | 32 | |
| Isiah Kiner-Falefa | SS | Pit | 30 | |
| Francisco Lindor | SS | NYN | 31 | |
| Sebastian Walcott | SS | Tex | 19 | |
| Jose Ramirez | 3B | Cle | 32 | |
| Randy Arozarena | OF | Sea | 30 | |
| Parker Meadows | OF | Det | 25 | March 24, 2025:60 Day IL |
| Cedric Mullins II | OF | Bal | 30 | |
| Heliot Ramos | OF | SF | 25 | |
| Chandler Simpson | OF | TB | 24 | |
| Taj Bradley | SP | TB | 24 | |
| Dylan Cease | SP | SD | 29 | |
| Michael King | SP | SD | 29 | |
| Bryce Miller | SP | Sea | 26 | |
| Tobias Myers | SP | Mil | N/A | |
| Ryan Pepiot | SP | TB | 27 | |
| Chris Sale | SP | Atl | 36 | |
| Tarik Skubal | SP | Det | 28 | |
| Spencer Strider | SP | Atl | 26 | April 21, 2025:15 Day IL |
| Framber Valdez | SP | Hou | 31 | |
| Hayden Wesneski | SP | Hou | 27 | |
| Yoshinobu Yamamoto | SP | LAD | 26 | |
| Anthony Bender | RP | Mia | 30 | |
| Kenley Jansen | RP | LAA | 37 | |
| Emilio Pagan | RP | Cin | 33 | |
| Will Vest | RP | Det | 29 |