| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Gabriel Moreno | C | Ari | 25 | |
| Austin Wells | C | NYA | 25 | |
| Luis Arraez | 1B | SD | 28 | |
| Joshua Bell | 1B | Was | 32 | |
| Tyler Soderstrom | 1B (OF) | Oak | 23 | |
| Otto Lopez | 2B | Mia | 26 | |
| Luis Rengifo | 2B (3B) | LAA | 28 | |
| Brice Turang | 2B | Mil | 25 | |
| Anthony Volpe | SS | NYA | 24 | |
| Masyn Winn | SS | StL | 23 | |
| Isaac Paredes | 3B | Hou | 26 | |
| Jose Ramirez | 3B | Cle | 32 | |
| Harrison Bader | OF | Min | 30 | |
| Cody Bellinger | OF | NYA | 29 | |
| JJ Bleday | OF | Oak | 27 | |
| Jackson Chourio | OF | Mil | 21 | |
| Pete Crow-Armstrong | OF | ChN | 23 | |
| Chase DeLauter | OF | Cle | 23 | |
| Spencer Steer | OF (1B) | Cin | 27 | |
| Tanner Bibee | SP | Cle | 26 | |
| Kevin Gausman | SP | Tor | 34 | |
| Tyler Glasnow | SP | LAD | 31 | April 29, 2025:15 Day IL |
| Merrill Kelly | SP | Ari | 36 | |
| Yusei Kikuchi | SP | LAA | 33 | |
| Bailey Ober | SP | Min | 29 | |
| Ryan Pepiot | SP | TB | 27 | |
| Quinn Priester | SP | Mil | 24 | |
| Clarke Schmidt | SP | NYA | 29 | |
| Jeffrey Springs | SP | Oak | 32 | |
| Justin Steele | SP | ChN | 29 | April 09, 2025:60 Day IL |
| Ranger Suarez | SP | Phi | 29 | March 23, 2025:15 Day IL |
| Jhoan Duran | RP | Min | 27 | |
| Mason Miller | RP | Oak | 26 | |
| Tanner Scott | RP | LAD | 30 |