| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| William Contreras | C | Mil | 27 | |
| Jonah Heim | C | Tex | 29 | |
| Carson Kelly | C | ChN | 30 | |
| Joshua Bell | 1B | Was | 32 | |
| Xavier Isaac | 1B | TB | 21 | |
| Spencer Torkelson | 1B | Det | 25 | |
| Nolan Gorman | 2B | StL | 24 | |
| Otto Lopez | 2B | Mia | 26 | |
| Leodalis De Vries | SS | SD | 18 | |
| Sebastian Walcott | SS | Tex | 19 | |
| Jett Williams | SS | NYN | 21 | |
| Bobby Witt Jr. | SS | KC | 24 | |
| Mark Vientos | 3B | NYN | 25 | |
| Lawrence Butler | OF | Oak | 24 | |
| Colton Cowser | OF | Bal | 25 | March 31, 2025:60 Day IL-Left thumb fracture |
| Jarren Duran | OF | Bos | 28 | |
| Ceddanne Rafaela | OF | Bos | 24 | |
| Julio Rodriguez | OF | Sea | 24 | |
| Juan Soto | OF | NYN | 26 | |
| Bubba Chandler | SP | Pit | N/A | |
| Hunter Dobbins | SP | Bos | N/A | |
| Luis Gil | SP | NYA | 26 | March 24, 2025:60 Day IL |
| MacKenzie Gore | SP | Was | 26 | |
| George Kirby | SP | Sea | 27 | March 27, 2025:15 Day IL |
| Andrew Painter | SP | Phi | N/A | |
| Eury Perez | SP | Mia | 22 | February 20, 2025:60 Day IL |
| Clarke Schmidt | SP | NYA | 29 | |
| JP Sears | SP | Oak | 29 | |
| Luis Severino | SP | Oak | 31 | |
| Tarik Skubal | SP | Det | 28 | |
| Michael Wacha | SP | KC | 33 | |
| Brandon Woodruff | SP | Mil | 32 | March 27, 2025:15 Day IL |
| Pete Fairbanks | RP | TB | 31 | |
| Justin Martinez | RP | Ari | 23 | May 01, 2025:15 Day IL |