| Position | Starters | Team | Opponents |
| C | Ivan Herrera | StL | Pit(3) @Was(3) |
| 1B | Josh Naylor | Ari | NYN(3) LAD(4) |
| 2B | Nolan Gorman | StL | Pit(3) @Was(3) |
| SS | CJ Abrams | Was | Cle(3) StL(3) |
| 3B | Josh Jung | Tex | @Bos(3) @Det(3) |
| OF | TJ Friedl | Cin | @Atl(4) @Hou(3) |
| OF | Bryan Reynolds | Pit | @StL(3) Atl(3) |
| OF | Julio Rodriguez | Sea | @Oak(3) Tor(3) |
| DH | Adolis Garcia | Tex | @Bos(3) @Det(3) |
| Position | 1st Backup | Team | Opponents |
| C | Pedro Pages | StL | Pit(3) @Was(3) |
| 1B | Ty France | Min | Bal(3) SF(3) |
| 2B | Luis Garcia | Was | Cle(3) StL(3) |
| SS | Jeremy Pena | Hou | @Mil(3) Cin(3) |
| 3B | Connor Norby | Mia | LAD(3) @ChA(3) |
| OF | Christopher Morel | TB | Phi(3) Mil(3) |
| DH | Ryan Jeffers | Min | Bal(3) SF(3) |
| Position | 2nd Backup | Team | Opponents |
| 1B | Jake Burger | Tex | @Bos(3) @Det(3) |
| Position | 3rd Backup | Team | Opponents |
| OF | Daulton Varsho | Tor | @LAA(3) @Sea(3) |
| Pitching Staff Alignment |
| 8 Starts, 1 Reliever |
| Position | Pitching Order | Team | Opponents | Next Scheduled Start(s) |
| 1st SP | Shota Imanaga | ChN | SF(3) @NYN(3) | This Saturday at NYN (Tylor Megill) |
| 2nd SP | Hunter Brown | Hou | @Mil(3) Cin(3) | Last Pitched Saturday May 3rd |
| 3rd SP | Nick Pivetta | SD | @NYA(3) @Col(3) | This Monday at NYA (Carlos Rodon) |
| 4th SP | Nathan Eovaldi | Tex | @Bos(3) @Det(3) | This Tuesday at Bos (Sean Newcomb) |
| 5th SP | Drew Rasmussen | TB | Phi(3) Mil(3) | This Tuesday vs Phi (Zack Wheeler) |
| 6th SP | Merrill Kelly | Ari | NYN(3) LAD(4) | This Wednesday vs NYN (Kodai Senga) |
| 7th SP | Shane Smith | ChA | @KC(4) Mia(3) |
This Monday at KC (Cole Ragans)
This Saturday vs Mia (Edward Cabrera) |
| 8th SP | Justin Verlander | SF | @ChN(3) @Min(3) | This Tuesday at ChN (Colin Rea) |
| 9th SP | Emerson Hancock | Sea | @Oak(3) Tor(3) | This Tuesday at Oak (Jeffrey Springs) |
| 10th SP | Zach Eflin | Bal | @Min(3) @LAA(3) | Last Pitched Monday April 7th |
| 11th SP | Logan Gilbert | Sea | @Oak(3) Tor(3) | Last Pitched Friday April 25th |
| 1st RP | Devin Williams | NYA | SD(3) @Oak(3) | Last Pitched Friday May 2nd |
| 2nd RP | Aroldis Chapman | Bos | Tex(3) @KC(3) | Last Pitched Wednesday April 30th |
| Position | Injured List | Team | Opponents |
| SP | Blake Snell | LAD | @Mia(3) @Ari(4) |
| SP | Lance McCullers | Hou | @Mil(3) Cin(3) |
| OF | Colton Cowser | Bal | @Min(3) @LAA(3) |