| Position | Starters | Team | Opponents |
| C | Shea Langeliers | Oak | Sea(3) NYA(3) |
| 1B | Josh Naylor | Ari | NYN(3) LAD(4) |
| 2B (OF) | Gavin Lux | Cin | @Atl(4) @Hou(3) |
| SS | Corey Seager | Tex | @Bos(3) @Det(3) |
| 3B | Matt Chapman | SF | @ChN(3) @Min(3) |
| OF | Aaron Judge | NYA | SD(3) @Oak(3) |
| OF (1B) | Pavin Smith | Ari | NYN(3) LAD(4) |
| OF | Jorge Soler | LAA | Tor(3) Bal(3) |
| DH | Marcell Ozuna | Atl | Cin(4) @Pit(3) |
| Position | 1st Backup | Team | Opponents |
| C | Bo Naylor | Cle | @Was(3) Phi(3) |
| 1B | Ben Rice | NYA | SD(3) @Oak(3) |
| 2B | Jeff McNeil | NYN | @Ari(3) ChN(3) |
| SS (3B) | Josh Smith | Tex | @Bos(3) @Det(3) |
| 3B (SS) | Oswaldo Cabrera | NYA | SD(3) @Oak(3) |
| OF | Ceddanne Rafaela | Bos | Tex(3) @KC(3) |
| DH | Nolan Gorman | StL | Pit(3) @Was(3) |
| Position | 2nd Backup | Team | Opponents |
| OF | Spencer Jones | NYA | SD(3) @Oak(3) |
| Pitching Staff Alignment |
| 5 Starts, 3 Relievers |
| Position | Pitching Order | Team | Opponents | Next Scheduled Start(s) |
| 1st SP | Chris Sale | Atl | Cin(4) @Pit(3) | This Tuesday vs Cin (Andrew Abbott) |
| 2nd SP | Aaron Nola | Phi | @TB(3) @Cle(3) | This Friday at Cle (Gavin Williams) |
| 3rd SP | Cristopher Sanchez | Phi | @TB(3) @Cle(3) | This Wednesday at TB (Shane Baz) |
| 4th SP | Nick Lodolo | Cin | @Atl(4) @Hou(3) | This Thursday at Atl (Spencer Schwellenbach) |
| 5th SP | Chris Bassitt | Tor | @LAA(3) @Sea(3) | This Thursday at LAA (José Soriano) |
| 6th SP | Merrill Kelly | Ari | NYN(3) LAD(4) | This Wednesday vs NYN (Kodai Senga) |
| 7th SP | Reese Olson | Det | @Col(3) Tex(3) | This Saturday vs Tex (Jacob deGrom) |
| 8th SP | Erick Fedde | StL | Pit(3) @Was(3) | This Friday at Was (Trevor Williams) |
| 9th SP | Jack Flaherty | Det | @Col(3) Tex(3) | This Friday vs Tex (Pat Corbin) |
| 10th SP | Lance McCullers | Hou | @Mil(3) Cin(3) | This Saturday vs Cin (Andrew Abbott) |
| 1st RP | Emmanuel Clase | Cle | @Was(3) Phi(3) | Last Pitched Saturday May 3rd |
| 2nd RP | Josh Hader | Hou | @Mil(3) Cin(3) | Last Pitched Tuesday April 29th |
| 3rd RP | Felix Bautista | Bal | @Min(3) @LAA(3) | Last Pitched Friday May 2nd |
| 4th RP | Will Vest | Det | @Col(3) Tex(3) | Last Pitched Tuesday April 29th |
| Position | Injured List | Team | Opponents |
| OF (2B) | Tommy Edman | LAD | @Mia(3) @Ari(4) |
| SP | Shane Bieber | Cle | @Was(3) Phi(3) |