| Position | Starters | Team | Opponents |
| C | William Contreras | Mil | Hou(3) @TB(3) |
| 1B | Josh Naylor | Ari | NYN(3) LAD(4) |
| 2B | Bryson Stott | Phi | @TB(3) @Cle(3) |
| SS | CJ Abrams | Was | Cle(3) StL(3) |
| 3B | Alec Bohm | Phi | @TB(3) @Cle(3) |
| OF | Wilyer Abreu | Bos | Tex(3) @KC(3) |
| OF | Jordan Beck | Col | Det(3) SD(3) |
| OF | Pete Crow-Armstrong | ChN | SF(3) @NYN(3) |
| DH | Shohei Ohtani | LAD | @Mia(3) @Ari(4) |
| Position | 1st Backup | Team | Opponents |
| C | Pedro Pages | StL | Pit(3) @Was(3) |
| 1B | Kyle Manzardo | Cle | @Was(3) Phi(3) |
| 2B | Marcus Semien | Tex | @Bos(3) @Det(3) |
| SS (3B,OF) | Javier Baez | Det | @Col(3) Tex(3) |
| 3B | Caleb Durbin | Mil | Hou(3) @TB(3) |
| OF | Heliot Ramos | SF | @ChN(3) @Min(3) |
| DH | Cody Bellinger | NYA | SD(3) @Oak(3) |
| Position | 2nd Backup | Team | Opponents |
| C | Samuel Basallo | Bal | @Min(3) @LAA(3) |
| 1B | Willson Contreras | StL | Pit(3) @Was(3) |
| SS | Sebastian Walcott | Tex | @Bos(3) @Det(3) |
| OF | Adolis Garcia | Tex | @Bos(3) @Det(3) |
| Position | 3rd Backup | Team | Opponents |
| 2B | Travis Bazzana | Cle | @Was(3) Phi(3) |
| OF | George Springer | Tor | @LAA(3) @Sea(3) |
| Pitching Staff Alignment |
| 5 Starts, 3 Relievers |
| Position | Pitching Order | Team | Opponents | Next Scheduled Start(s) |
| 1st SP | Jacob deGrom | Tex | @Bos(3) @Det(3) | Last Pitched Tuesday April 29th |
| 2nd SP | Cristopher Sanchez | Phi | @TB(3) @Cle(3) | This Wednesday at TB (Shane Baz) |
| 3rd SP | Jackson Jobe | Det | @Col(3) Tex(3) | This Tuesday at Col (Chase Dollander) |
| 4th SP | MacKenzie Gore | Was | Cle(3) StL(3) | Last Pitched Tuesday April 29th |
| 5th SP | Andrew Painter | Phi | @TB(3) @Cle(3) | Has Not Played Yet |
| 6th SP | Lucas Giolito | Bos | Tex(3) @KC(3) | Last Pitched Wednesday April 30th |
| 1st RP | Mason Miller | Oak | Sea(3) NYA(3) | Last Pitched Thursday May 1st |
| 2nd RP | Emmanuel Clase | Cle | @Was(3) Phi(3) | Last Pitched Wednesday April 30th |
| 3rd RP | Trevor Megill | Mil | Hou(3) @TB(3) | Last Pitched Wednesday April 30th |
| Position | Injured List | Team | Opponents |
| SP | Eury Perez | Mia | LAD(3) @ChA(3) |
| 2B | Luke Keaschall | Min | Bal(3) SF(3) |
| SP | George Kirby | Sea | @Oak(3) Tor(3) |