| Position | Starters | Team | Opponents |
| C | Logan O'Hoppe | LAA | Tor(3) Bal(3) |
| 1B | Matt Olson | Atl | Cin(4) @Pit(3) |
| 2B | Gleyber Torres | Det | @Col(3) Tex(3) |
| SS | Francisco Lindor | NYN | @Ari(3) ChN(3) |
| 3B | Eugenio Suarez | Ari | NYN(3) LAD(4) |
| OF | Ian Happ | ChN | SF(3) @NYN(3) |
| OF | Brandon Nimmo | NYN | @Ari(3) ChN(3) |
| OF | Bryan Reynolds | Pit | @StL(3) Atl(3) |
| DH | Dansby Swanson | ChN | SF(3) @NYN(3) |
| Position | 1st Backup | Team | Opponents |
| C | Joey Bart | Pit | @StL(3) Atl(3) |
| 1B | Joshua Bell | Was | Cle(3) StL(3) |
| OF | Nick Castellanos | Phi | @TB(3) @Cle(3) |
| DH | Victor Scott | StL | Pit(3) @Was(3) |
| Position | 2nd Backup | Team | Opponents |
| OF | George Springer | Tor | @LAA(3) @Sea(3) |
| Position | Bench | Team | Opponents |
| 2B (SS,3B) | Willi Castro | Min | Bal(3) SF(3) |
| OF | Jake Fraley | Cin | @Atl(4) @Hou(3) |
| Pitching Staff Alignment |
| 7 Starts, 2 Relievers |
| Position | Pitching Order | Team | Opponents | Next Scheduled Start(s) |
| 1st SP | Nick Pivetta | SD | @NYA(3) @Col(3) | Last Pitched Tuesday April 29th |
| 2nd SP | Dylan Cease | SD | @NYA(3) @Col(3) | This Wednesday at NYA (Max Fried) |
| 3rd SP | Framber Valdez | Hou | @Mil(3) Cin(3) | This Wednesday at Mil (Quinn Priester) |
| 4th SP | Logan Webb | SF | @ChN(3) @Min(3) | Last Pitched Tuesday April 29th |
| 5th SP | Erick Fedde | StL | Pit(3) @Was(3) | Last Pitched Sunday April 27th |
| 6th SP | Chris Bassitt | Tor | @LAA(3) @Sea(3) | This Thursday at LAA (José Soriano) |
| 7th SP | Andrew Heaney | Pit | @StL(3) Atl(3) | Last Pitched Tuesday April 29th |
| 8th SP | Jose Berrios | Tor | @LAA(3) @Sea(3) | This Wednesday at LAA (Yusei Kikuchi) |
| 9th SP | Jameson Taillon | ChN | SF(3) @NYN(3) | This Friday at NYN (Clay Holmes) |
| 10th SP | AJ Smith-Shawver | Atl | Cin(4) @Pit(3) | This Monday vs Cin (Brady Singer) |
| 1st RP | Josh Hader | Hou | @Mil(3) Cin(3) | Last Pitched Tuesday April 29th |
| 2nd RP | Jeff Hoffman | Tor | @LAA(3) @Sea(3) | Last Pitched Friday May 2nd |
| 3rd RP | Kenley Jansen | LAA | Tor(3) Bal(3) | Last Pitched Friday May 2nd |
| 4th RP | Emilio Pagan | Cin | @Atl(4) @Hou(3) | Last Pitched Friday May 2nd |
| 5th RP | Will Vest | Det | @Col(3) Tex(3) | Last Pitched Tuesday April 29th |
| Position | Injured List | Team | Opponents |
| 3B (2B,OF) | Dylan Moore | Sea | @Oak(3) Tor(3) |
| SP | Aaron Civale | Mil | Hou(3) @TB(3) |