| Position | Starters | Team | Opponents |
| C | Shea Langeliers | Oak | Sea(3) NYA(3) |
| 1B | Matt Olson | Atl | Cin(4) @Pit(3) |
| 2B | Gleyber Torres | Det | @Col(3) Tex(3) |
| SS | Willy Adames | SF | @ChN(3) @Min(3) |
| 3B | Alex Bregman | Bos | Tex(3) @KC(3) |
| OF | Aaron Judge | NYA | SD(3) @Oak(3) |
| OF | Jurickson Profar | Atl | Cin(4) @Pit(3) |
| OF | Brent Rooker | Oak | Sea(3) NYA(3) |
| DH | Nick Castellanos | Phi | @TB(3) @Cle(3) |
| Position | 1st Backup | Team | Opponents |
| C | Keibert Ruiz | Was | Cle(3) StL(3) |
| 1B | Joshua Bell | Was | Cle(3) StL(3) |
| 2B | Jeff McNeil | NYN | @Ari(3) ChN(3) |
| SS (3B) | Paul DeJong | Was | Cle(3) StL(3) |
| 3B | Eugenio Suarez | Ari | NYN(3) LAD(4) |
| OF | George Springer | Tor | @LAA(3) @Sea(3) |
| DH | Wilyer Abreu | Bos | Tex(3) @KC(3) |
| Pitching Staff Alignment |
| 10 Starts, 0 Relievers |
| Position | Pitching Order | Team | Opponents | Next Scheduled Start(s) |
| 1st SP | Logan Gilbert | Sea | @Oak(3) Tor(3) | Last Pitched Friday April 25th |
| 2nd SP | Chris Sale | Atl | Cin(4) @Pit(3) | This Tuesday vs Cin (Andrew Abbott) |
| 3rd SP | Sonny Gray | StL | Pit(3) @Was(3) | This Friday at Was (Trevor Williams) |
| 4th SP | Hunter Brown | Hou | @Mil(3) Cin(3) | This Friday vs Cin (Nick Martinez) |
| 5th SP | Mike Soroka | Was | Cle(3) StL(3) | Last Pitched Monday March 31st |
| 6th SP | MacKenzie Gore | Was | Cle(3) StL(3) | Last Pitched Tuesday April 29th |
| 7th SP | Ryan Pepiot | TB | Phi(3) Mil(3) | This Thursday vs Phi (Jesus Luzardo) |
| 8th SP | Max Scherzer | Tor | @LAA(3) @Sea(3) | Last Pitched Saturday March 29th |
| 9th SP | Bowden Francis | Tor | @LAA(3) @Sea(3) | Last Pitched Tuesday April 29th |
| 10th SP | Trevor Williams | Was | Cle(3) StL(3) | This Friday vs StL (Sonny Gray) |
| 11th SP | Nick Martinez | Cin | @Atl(4) @Hou(3) | This Friday at Hou (Hunter Brown) |
| 12th SP | Brandon Woodruff | Mil | Hou(3) @TB(3) | Has Not Played Yet |
| 13th SP | Jake Irvin | Was | Cle(3) StL(3) | This Monday vs Cle (Luis Ortiz) |
| 1st RP | Chris Martin | Tex | @Bos(3) @Det(3) | Last Pitched Wednesday April 30th |