*=Defensive Player of the Week
| Rank | Score | Week | Proteam | Opponent | Breakdown |
| 1. | 24.00 | Week 14, 2016 * | SF | NYJNYJ | 9 Tackles, 3 Assists, 1.0 Sack, 1 Int, 3 PD |
| 2. | 20.00 | Week 10, 2021 | SF | LARLAR | 2 Tackles, 2 Int, 1 TD, 2 PD |
| 3. | 19.00 | Week 13, 2015 | SF | @Chi@Chi | 1 Tackle, 1 Assist, 1 Int, 1 TD, 1 PD |
| 4. | 18.00 | Week 12, 2024 | Hou | TenTen | 6 Tack, 1 Int, 1 TD, 1 PD |
| 5. | 13.00 | Week 11, 2019 | SF | AriAri | 7 Tackles, 1 Assist, 1.0 Sack, 1 PD |
| 6. | 12.00 | Week 13, 2023 | Hou | DenDen | 4 Tackles, 2 Assists, 1 Int, 1 PD |
| 6. | 12.00 | Week 14, 2022 | SF | TBTB | 6 Tackles, 2 Assists, 1 FF, 1 PD |
| 6. | 12.00 | Week 12, 2020 | SF | @LAR@LAR | 4 Tackles, 1 Assist, 2 FF, 1 PD |
| 9. | 11.00 | Week 10, 2024 | Hou | DetDet | 4 Tack, 1 Ass, 1 Int, 1 PD |
| 9. | 11.00 | Week 13, 2022 | SF | MiaMia | 4 Tackles, 1 Assist, 1 Int, 1 PD |
| 9. | 11.00 | Week 11, 2022 | SF | @Ari@Ari | 3 Tackles, 2 Assists, 1 Int, 1 PD |
| 9. | 11.00 | Week 10, 2016 | SF | @Ari@Ari | 7 Tackles, 4 PD |
| 9. | 11.00 | Week 17, 2015 | SF | StlStl | 9 Tackles, 1 Assist, 1 PD |
| 14. | 10.00 | Week 15, 2024 | Hou | MiaMia | 4 Tack, 5 Ass, 1 PD |
| 14. | 10.00 | Week 16, 2022 | SF | WasWas | 4 Tackles, 1 Int, 1 PD |
| 14. | 10.00 | Week 13, 2016 | SF | @Chi@Chi | 4 Tackles, 1 FF, 1 Fum Rcvy |
| 14. | 10.00 | Week 15, 2015 | SF | CinCin | 4 Tackles, 1 Assist, 1.0 Sack, 1 PD |
| 18. | 9.00 | Week 08, 2023 | Hou | @Car@Car | 3 Tackles, 5 Assists, 1 PD |
| 18. | 9.00 | Week 02, 2016 | SF | @Car@Car | 5 Tackles, 4 Assists |
| 20. | 8.00 | Week 03, 2023 | Hou | @Jac@Jac | 5 Tackles, 3 Assists |
| 20. | 8.00 | Week 05, 2020 | SF | MIAMIA | 6 Tackles, 2 Assists |
| 20. | 8.00 | Week 14, 2019 | SF | @NO@NO | 6 Tackles, 2 Assists |
| 20. | 8.00 | Week 12, 2019 | SF | GBGB | 5 Tackles, 1 Assist, 2 PD |
| 20. | 8.00 | Week 10, 2019 | SF | SeaSea | 4 Tackles, 3 Assists, 1 PD |
| 20. | 8.00 | Week 06, 2019 | SF | @LAR@LAR | 6 Tackles, 2 PD |
| 20. | 8.00 | Week 05, 2015 | SF | @NYG@NYG | 7 Tackles, 1 Assist |
| 27. | 7.00 | Week 02, 2024 | Hou | ChiChi | 6 Tack, 1 Ass |
| 27. | 7.00 | Week 14, 2023 | Hou | @NYJ@NYJ | 5 Tackles, 2 Assists |
| 27. | 7.00 | Week 06, 2023 | Hou | NONO | 5 Tackles, 2 Assists |
| 27. | 7.00 | Week 05, 2023 | Hou | @Atl@Atl | 5 Tackles, 1 Assist, 1 PD |
| 27. | 7.00 | Week 04, 2023 | Hou | PitPit | 2 Tackles, 2 Assists, 1 FF |
| 27. | 7.00 | Week 17, 2022 | SF | @LV@LV | 6 Tackles, 1 Assist |
| 27. | 7.00 | Week 07, 2021 | SF | INDIND | 5 Tackles, 2 Assists |
| 27. | 7.00 | Week 02, 2021 | SF | @PHI@PHI | 4 Tackles, 2 Assists, 1 PD |
| 27. | 7.00 | Week 14, 2020 | SF | WASWAS | 2 Tackles, 5 Assists |
| 27. | 7.00 | Week 13, 2020 | SF | BUFBUF | 3 Tackles, 4 Assists |
| 27. | 7.00 | Week 13, 2019 | SF | @Bal@Bal | 4 Tackles, 2 Assists, 1 PD |
| 27. | 7.00 | Week 03, 2017 | SF | LARLAR | 7 Tackles |
| 27. | 7.00 | Week 09, 2015 | SF | AtlAtl | 5 Tackles, 1 Assist, 1 PD |
| 40. | 6.00 | Week 13, 2024 | Hou | @Jac@Jac | 3 Tack, 3 Ass |
| 40. | 6.00 | Week 18, 2021 | SF | @LAR@LAR | 2 Tackles, 4 Assists |
| 40. | 6.00 | Week 14, 2021 | SF | @CIN@CIN | 3 Tackles, 2 Assists, 1 PD |
| 40. | 6.00 | Week 08, 2021 | SF | @CHI@CHI | 6 Tackles |
| 40. | 6.00 | Week 05, 2021 | SF | @ARI@ARI | 3 Tackles, 3 Assists |
| 40. | 6.00 | Week 01, 2021 | SF | @DET@DET | 4 Tackles, 2 Assists |
| 40. | 6.00 | Week 10, 2020 | SF | @NO@NO | 2 Tackles, 2 Assists, 2 PD |
| 40. | 6.00 | Week 08, 2020 | SF | @SEA@SEA | 5 Tackles, 1 Assist |
| 40. | 6.00 | Week 02, 2020 | SF | @NYJ@NYJ | 3 Tackles, 3 Assists |
| 40. | 6.00 | Week 09, 2019 | SF | @Ari@Ari | 5 Tackles, 1 Assist |
| 40. | 6.00 | Week 07, 2017 | SF | DalDal | 6 Tackles |