*=Defensive Player of the Week
| Rank | Score | Week | Proteam | Opponent | Breakdown |
| 1. | 9.00 | Week 15, 2021 | Cle | LVLV | 4 Tackles, 3 Assists, 0.5 Sack |
| 1. | 9.00 | Week 17, 2017 | SF | @LAR@LAR | 4 Tackles, 1 Assist, 1.0 Sack |
| 3. | 8.00 | Week 10, 2024 | Was | PitPit | 4 Tack, 4 Ass |
| 4. | 6.00 | Week 15, 2019 | SF | AtlAtl | 2 Tackles, 1.0 Sack |
| 4. | 6.00 | Week 07, 2017 | Jac | @Ind@Ind | 1 Tackle, 1.0 Sack, 1 PD |
| 6. | 5.00 | Week 12, 2024 | Was | DalDal | 1 Tack, 4 Ass |
| 6. | 5.00 | Week 06, 2021 | Cle | ARIARI | 2 Tackles, 3 Assists |
| 6. | 5.00 | Week 06, 2018 | SF | @GB@GB | 1 Tackle, 1.0 Sack |
| 6. | 5.00 | Week 04, 2018 | SF | @LAC@LAC | 1 Tackle, 1.0 Sack |
| 6. | 5.00 | Week 16, 2016 | Jac | TenTen | 1 Tackle, 1.0 Sack |
| 11. | 4.00 | Week 16, 2024 | Was | PhiPhi | 2 Tack, 1 Ass, 1 PD |
| 11. | 4.00 | Week 16, 2021 | Cle | @GB@GB | 4 Assists |
| 11. | 4.00 | Week 09, 2021 | Cle | @CIN@CIN | 2 Assists, 0.5 Sack |
| 14. | 3.00 | Week 17, 2021 | Cle | @PIT@PIT | 2 Assists, 1 PD |
| 14. | 3.00 | Week 07, 2018 | SF | LARLAR | 2 Tackles, 1 Assist |
| 14. | 3.00 | Week 13, 2017 | SF | @Chi@Chi | 3 Tackles |
| 17. | 2.00 | Week 09, 2024 | Was | @NYG@NYG | 1 Tack, 1 Ass |
| 17. | 2.00 | Week 07, 2024 | Was | CarCar | 2 Tack |
| 17. | 2.00 | Week 15, 2023 | Min | @Cin@Cin | 2 Assists |
| 17. | 2.00 | Week 14, 2021 | Cle | BALBAL | 1 Tackle, 1 PD |
| 17. | 2.00 | Week 16, 2019 | SF | LARLAR | 1 Tackle, 1 Assist |
| 17. | 2.00 | Week 02, 2019 | SF | @Cin@Cin | |
| 17. | 2.00 | Week 12, 2018 | SF | @TB@TB | 2 Tackles |
| 17. | 2.00 | Week 16, 2017 | SF | JacJac | 1 Tackle, 1 Assist |
| 17. | 2.00 | Week 15, 2017 | SF | TenTen | 2 Tackles |
| 17. | 2.00 | Week 14, 2017 | SF | @Hou@Hou | 2 Assists |
| 17. | 2.00 | Week 12, 2017 | SF | SeaSea | 2 Tackles |
| 28. | 1.00 | Week 17, 2024 | Was | AtlAtl | 1 Ass |
| 28. | 1.00 | Week 15, 2024 | Was | @NO @NO | 1 Ass |
| 28. | 1.00 | Week 11, 2024 | Was | @Phi@Phi | 1 Tack |
| 28. | 1.00 | Week 01, 2024 | Was | @TB @TB | 1 Tack |
| 28. | 1.00 | Week 17, 2023 | Min | GBGB | 1 Assist |
| 28. | 1.00 | Week 14, 2023 | Min | @LV@LV | 1 Tackle |
| 28. | 1.00 | Week 12, 2021 | Cle | @BAL@BAL | 1 Assist |
| 28. | 1.00 | Week 10, 2020 | Ind | @TEN@TEN | 1 Assist |
| 28. | 1.00 | Week 08, 2020 | Ind | @DET@DET | 1 PD |
| 28. | 1.00 | Week 06, 2020 | Ind | CINCIN | 1 Tackle |
| 28. | 1.00 | Week 17, 2019 | SF | @Sea@Sea | 1 Tackle |
| 28. | 1.00 | Week 14, 2019 | SF | @NO@NO | 1 Tackle |
| 28. | 1.00 | Week 13, 2019 | SF | @Bal@Bal | 1 Assist |
| 28. | 1.00 | Week 12, 2019 | SF | GBGB | 1 Tackle |
| 28. | 1.00 | Week 08, 2019 | SF | CarCar | 1 Tackle |
| 28. | 1.00 | Week 07, 2019 | SF | @Was@Was | 1 Tackle |
| 28. | 1.00 | Week 05, 2019 | SF | CleCle | 1 Assist |
| 28. | 1.00 | Week 03, 2019 | SF | PitPit | 1 Assist |
| 28. | 1.00 | Week 01, 2019 | SF | @TB@TB | 1 Tackle |
| 28. | 1.00 | Week 09, 2018 | SF | OakOak | 1 Tackle |
| 28. | 1.00 | Week 08, 2018 | SF | @Ari@Ari | 1 Tackle |
| 28. | 1.00 | Week 03, 2018 | SF | @KC@KC | 1 PD |
| 28. | 1.00 | Week 02, 2018 | SF | DetDet | 1 PD |