*=Defensive Player of the Week
| Rank | Score | Week | Proteam | Opponent | Breakdown |
| 1. | 26.00 | Week 02, 2024 | SF | @Min@Min | 7 Tack, 2 Ass, 1.00 Sack, 1 Int, 2 FF, 2 PD |
| 2. | 23.00 | Week 16, 2020 | SF | @ARI@ARI | 8 Tackles, 6 Assists, 1 FF, 1 Fum Rcvy, 3 PD |
| 2. | 23.00 | Week 16, 2019 | SF | LARLAR | 8 Tackles, 3 Assists, 1 Int, 1 TD, 1 PD |
| 4. | 22.00 | Week 10, 2019 | SF | SeaSea | 9 Tackles, 1 Assist, 2.0 Sacks, 1 FF, 1 PD |
| 5. | 21.00 | Week 05, 2023 * | SF | DalDal | 5 Tackles, 3 Assists, 1.0 Sack, 1 Int, 1 FF, 1 PD |
| 6. | 19.00 | Week 04, 2024 | SF | NE NE | 4 Tack, 3 Ass, 1 Int, 1 TD, 1 PD |
| 6. | 19.00 | Week 11, 2023 | SF | TBTB | 10 Tackles, 2 Assists, 0.5 Sack, 1 FF, 2 PD |
| 8. | 18.00 | Week 17, 2021 | SF | HOUHOU | 7 Tackles, 8 Assists, 1 FF |
| 8. | 18.00 | Week 12, 2019 | SF | GBGB | 11 Tackles, 1.0 Sack, 1 FF |
| 10. | 17.00 | Week 08, 2022 | SF | @LAR@LAR | 5 Tackles, 7 Assists, 1.0 Sack, 1 PD |
| 11. | 16.00 | Week 15, 2024 | SF | LARLAR | 8 Tack, 7 Ass, 1 PD |
| 11. | 16.00 | Week 02, 2023 | SF | @LAR@LAR | 9 Tackles, 2 Assists, 1.0 Sack, 1 PD |
| 11. | 16.00 | Week 01, 2018 | SF | @Min@Min | 11 Tackles, 1 Assist, 1 FF, 1 PD |
| 14. | 15.00 | Week 06, 2024 | SF | @Sea@Sea | 6 Tack, 5 Ass, 1 FF, 1 PD |
| 15. | 14.00 | Week 15, 2023 | SF | @Ari@Ari | 8 Tackles, 1 Assist, 0.5 Sack, 1 FF |
| 15. | 14.00 | Week 14, 2023 | SF | SeaSea | 4 Tackles, 4 Assists, 1 Int, 1 PD |
| 15. | 14.00 | Week 07, 2023 | SF | @Min@Min | 7 Tackles, 6 Assists, 1 PD |
| 15. | 14.00 | Week 05, 2022 | SF | @Car@Car | 7 Tackles, 2 Assists, 1.0 Sack, 1 PD |
| 15. | 14.00 | Week 09, 2021 | SF | ARIARI | 6 Tackles, 8 Assists |
| 15. | 14.00 | Week 17, 2020 | SF | SEASEA | 8 Tackles, 2 Assists, 1.0 Sack |
| 15. | 14.00 | Week 17, 2018 | SF | @LAR@LAR | 9 Tackles, 5 Assists |
| 22. | 13.00 | Week 10, 2023 | SF | @Jac@Jac | 4 Tackles, 3 Assists, 1 Int, 1 PD |
| 22. | 13.00 | Week 08, 2023 | SF | CinCin | 4 Tackles, 6 Assists, 1 FF |
| 22. | 13.00 | Week 06, 2023 | SF | @Cle@Cle | 3 Tackles, 4 Assists, 1 Int, 1 PD |
| 22. | 13.00 | Week 16, 2022 | SF | WasWas | 8 Tackles, 5 Assists |
| 22. | 13.00 | Week 15, 2021 | SF | ATLATL | 6 Tackles, 3 Assists, 1 Fum Rcvy, 1 PD |
| 22. | 13.00 | Week 09, 2020 | SF | GBGB | 9 Tackles, 4 Assists |
| 22. | 13.00 | Week 07, 2020 | SF | @NE@NE | 3 Tackles, 4 Assists, 1 Int, 1 PD |
| 22. | 13.00 | Week 03, 2020 | SF | @NYG@NYG | 2 Tackles, 5 Assists, 1 Int, 1 PD |
| 22. | 13.00 | Week 13, 2019 | SF | @Bal@Bal | 8 Tackles, 3 Assists, 2 PD |
| 22. | 13.00 | Week 01, 2019 | SF | @TB@TB | 7 Tackles, 2 Assists, 1 FF, 1 PD |
| 32. | 12.00 | Week 05, 2024 | SF | AriAri | 7 Tack, 5 Ass |
| 32. | 12.00 | Week 16, 2023 | SF | BalBal | |
| 32. | 12.00 | Week 17, 2022 | SF | @LV@LV | 4 Tackles, 8 Assists |
| 32. | 12.00 | Week 12, 2022 | SF | NONO | 5 Tackles, 2 Assists, 1 FF, 2 PD |
| 32. | 12.00 | Week 07, 2021 | SF | INDIND | 7 Tackles, 2 Assists, 1 Fum Rcvy |
| 32. | 12.00 | Week 02, 2020 | SF | @NYJ@NYJ | 9 Tackles, 3 Assists |
| 32. | 12.00 | Week 11, 2019 | SF | AriAri | 9 Tackles, 3 Assists |
| 32. | 12.00 | Week 03, 2018 | SF | @KC@KC | 9 Tackles, 2 Assists, 1 PD |
| 40. | 11.00 | Week 16, 2024 | SF | @Mia@Mia | 6 Tack, 5 Ass |
| 40. | 11.00 | Week 01, 2021 | SF | @DET@DET | 8 Tackles, 3 Assists |
| 40. | 11.00 | Week 05, 2020 | SF | MIAMIA | 8 Tackles, 3 Assists |
| 40. | 11.00 | Week 01, 2020 | SF | AriAri | 6 Tackles, 4 Assists, 1 PD |
| 44. | 10.00 | Week 01, 2024 | SF | NYJNYJ | 5 Tack, 2 Ass, 1 FF |
| 44. | 10.00 | Week 04, 2023 | SF | AriAri | 8 Tackles, 2 Assists |
| 44. | 10.00 | Week 13, 2022 | SF | MiaMia | 2 Tackles, 1 Assist, 1 Int, 2 PD |
| 44. | 10.00 | Week 11, 2022 | SF | @Ari@Ari | 5 Tackles, 1 Assist, 1.0 Sack |
| 44. | 10.00 | Week 10, 2022 | SF | LACLAC | 4 Tackles, 3 Assists, 3 PD |
| 44. | 10.00 | Week 06, 2022 | SF | @Atl@Atl | 8 Tackles, 2 Assists |
| 44. | 10.00 | Week 18, 2021 | SF | @LAR@LAR | 5 Tackles, 3 Assists, 0.5 Sack |